TITLE

Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet

AUTHOR(S)
Višković, Klaudija; Rutherford, George W.; Sudario, Gabriel; Stemberger, Lorna; Brnić, Zoran; Begovac, Josip
PUB. DATE
August 2013
SOURCE
Croatian Medical Journal;Aug2013, Vol. 54 Issue 4, p330
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim To evaluate the influence of food habits, specifically adherence to the Mediterranean diet, on carotid intimamedia thickness (CIMT) and the presence of plaques in HIV-infected patients taking antiretroviral therapy (ART) and non-HIV-infected participants and to determine if HIV infection contributes independently to subclinical atherosclerosis. Methods We conducted a cross-sectional study of 110 HIV-infected patients on ART and 131 non-HIV-infected participants at the University Hospital for Infectious Diseases in Zagreb, Croatia, from 2009-2011. CIMT measurement and determination of carotid plaque presence was detected by ultrasound. Adherence to the Mediterranean diet was assessed by a 14-point food-item questionnaire. Subclinical atherosclerosis was defined by CIMT≥0.9 mm or ≥1 carotid plaque. Results In HIV-infected patients, subclinical atherosclerosis was associated with older age (P < 0.001; Mann-Whitney test), higher body mass index (P = 0.051; Mann-Whitney test), hypertension (P < 0.001; ?² test), and a lower Mediterranean diet score (P = 0.035; Mann-Whitney test), and in non-HIV-infected participants with older age (P < 0.001; Mann-Whitney test) and hypertension (P = 0.006; ?² test). Multivariate analysis showed that decreased adherence to the Mediterranean diet was associated with higher odds of subclinical atherosclerosis (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.10-4.72, P = 0.027) as was current smoking (OR 2.86, 95% CI 1.28-6.40), hypertension (OR 3.04, 95% CI 1.41-6.57), and male sex (OR 2.35, 95% CI 0.97- 5.70). There was a significant interaction of age and HIV status, suggesting that older HIV-infected patients had higher odds of subclinical atherosclerosis than controls (OR 3.28, 95% CI 1.24-8.71, P = 0.017 at the age of 60 years). Conclusion We confirmed the association between lower adherence to the Mediterranean diet and increased risk of subclinical atherosclerosis and found that treated HIV infection was a risk factor for subclinical atherosclerosis in older individuals.
ACCESSION #
90507698

 

Related Articles

  • Arterial stiffness and carotid intima-media thickness in HIV infected patients. Papiţă, Anamaria; Albu, Adriana; Fodor, Daniela; Itu, Corina; Cârstina, Dumitru // Medical Ultrasonography;Jun2011, Vol. 13 Issue 2, p127 

    Background: Cardiovascular disease is an increasing cause of morbidity and mortality in HIV-infected patients. The increased cardiovascular risk is linked to traditional risk factors for atherosclerosis but also, to HIV infection itself which can damage the arterial wall and the antiretroviral...

  • Frequency of HIV-1 Viral Load Monitoring of Patients Initially Successfully Treated with Combination Antiretroviral Therapy. Romih, Vanja; Lepej, Snježana żidovec; Gedike, Kornelija; Lukas, Davorka; Begovac, Josip // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Background: Although considered an essential tool for monitoring the effect of combination antiretroviral treatment (CART), HIV-1 RNA (viral load, VL) testing is greatly influenced by cost and availability of resources. Objectives: To examine whether HIV infected patients who were initially...

  • ORAL ABSTRACTS.  // Journal of the International AIDS Society;2014 Supplement 3, Vol. 17 Issue Supp 3, p439 

    The article presents abstracts on HIV drug therapy including curing HIV, normalisation of CD4/CD8 ratio with antiretroviral therapy in HIV infection and determinants of IL-6 levels during the HIV infection.

  • CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals. Zaunders, John; Danta, Mark; Bailey, Michelle; Mak, Gerald; Marks, Katherine; Seddiki, Nabila; Yin Xu; Templeton, David J.; Cooper, David A.; Boyd, Mark A.; Kelleher, Anthony D.; Koelsch, Kersten K. // Frontiers in Immunology;10/24/2016, Vol. 7, p1 

    Background: Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4+ T cells in gut-associated lymphoid tissue (GALT), but...

  • Trends in Antiretroviral Drug Use During Pregnancy Among HIV-Infected Women on Medicaid: 2000-2007. Phiri, Kelesitse; Fischer, Michael A.; Mogun, Helen; Williams, Paige L.; Palmsten, Kristin; Seage, George R.; Hernandez-Diaz, Sonia // AIDS Patient Care & STDs;Feb2014, Vol. 28 Issue 2, p56 

    Optimal use of antiretroviral drugs by pregnant women living with human immunodeficiency virus (HIV) is crucial to treat maternal HIV infection and prevent perinatal transmission of the virus effectively. Our goal was to describe national trends of antiretroviral (ARV) use during pregnancy among...

  • Prevalence and Factors Associated with Renal Dysfunction Among HIV-Infected Patients. Crum-Cianflone, Nancy; Ganesan, Anuradha; Teneza-Mora, Nimfa; Riddle, Mark; Medina, Sheila; Barahona, Irma; Brodine, Stephanie // AIDS Patient Care & STDs;Jun2010, Vol. 24 Issue 6, p353 

    Renal dysfunction is an increasingly recognized non-AIDS–defining comorbidity among HIV-infected persons. The role of HIV-related factors in renal dysfunction remains unclear. We performed a cross-sectional study at two military clinics with open access to care to determine the impact of...

  • HIV treatment prevents transmission of HIV.  // Africa Health;May2011, Vol. 33 Issue 4, p11 

    The article discusses the report from the US National Institutes of Health which found that an effective antiretroviral therapy regimen for HIV-positive person could prevent the risk of transmitting the virus to their uninfected sexual partner.

  • Ultrasound-assessed perirenal fat is related to increased ophthalmic artery resistance index in HIV-1 patients. Grima, Pierfrancesco; Guido, Marcello; Chiavaroli, Roberto; Zizza, Antonella // Cardiovascular Ultrasound;2010, Vol. 8, p24 

    Background: The introduction of highly active antiretroviral therapy (HAART) has dramatically changed the prognosis of human immunodeficiency virus (HIV) infection, with a significant decline in morbidity and mortality. Changes in body fat distribution are a common finding in individuals with...

  • Detection of immunological treatment failure among HIV infected patients in Ethiopia: a retrospective cohort study. Teshome, Wondu; Tefera, Ambachew // BMC Immunology;9/17/2015, Vol. 16 Issue 1, p1 

    Background: Timely detection of treatment failure with subsequent switch to second-line regimen reduces mortality among HIV infected people on antiretroviral therapy (ART). This paper aims to investigate the detection of immunological treatment failure and switch rate to second line regimen in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics