Adekunle Onifade, Abdulfatah; Jewell, Andrew Paul; Adeola Adedeji, Waheed
September 2013
African Journal of Traditional, Complementary & Alternative Medi;2013, Vol. 10 Issue 5, p332
Academic Journal
Nigella sativa had been documented to possess many therapeutic functions in medicine but the least expected is sero-reversion in HIV infection which is very rare despite extensive therapy with highly active anti-retroviral therapy (HAART). This case presentation is to highlight the complete recovery and sero-reversion of adult HIV patient after treatment with Nigella sativa concoction for the period of six months. The patient presented to the herbal therapist with history of chronic fever, diarrhoea, weight loss and multiple papular pruritic lesions of 3 months duration. Examination revealed moderate weight loss, and the laboratory tests of ELISA (Genscreen) and western blot (new blot 1 & 2) confirmed sero-positivity to HIV infection with pre-treatment viral (HIV-RNA) load and CD4 count of 27,000 copies/ml and CD4 count of 250 cells/ mm3 respectively. The patient was commenced on Nigella sativa concoction 10mls twice daily for 6 months.. He was contacted daily to monitor side-effects and drug efficacy. Fever, diarrhoea and multiple pruritic lesions disappeared on 5th, 7th and 20th day respectively on Nigella sativa therapy. The CD4 count decreased to 160 cells/ mm3 despite significant reduction in viral load (⩽1000 copies/ml) on 30th day on N. sativa. Repeated EIA and Western blot tests on 187th day on Nigella sativa therapy was sero-negative. The post therapy CD4 count was 650cells/ mm3 with undetectable viral (HIV-RNA) load. Several repeats of the HIV tests remained seronegative, aviraemia and normal CD4 count since 24 months without herbal therapy. This case report reflects the fact that there are possible therapeutic agents in Nigella sativa that may effectively control HIV infection.


Related Articles

  • Prevalence of Pulmonary Tuberculosis Among HIV Positive Patients Attending Antiretroviral Therapy Clinic. Giri, Purushottam A.; Deshpande, Jayant D.; Phalke, Deepak B. // North American Journal of Medical Sciences;Jun2013, Vol. 5 Issue 6, p367 

    Background: Tuberculosis (TB) is the most common serious opportunistic infection in HIV positive patients and is the manifestation of AIDS in more than 50% of cases in developing countries. TB can occur at any time during the course of HIV infection. Aim: To describe the socio-demographic...

  • The future of antiretroviral therapy: challenges and needs. Moreno, Santiago; López Aldeguer, Jose; Arribas, José Ramón; Domingo, Pere; Iribarren, Jose Antonio; Ribera, Esteban; Rivero, Antonio; Pulido, Federico // Journal of Antimicrobial Chemotherapy (JAC);May2010, Vol. 65 Issue 5, p827 

    The introduction of combination antiretroviral therapy (cART) has substantially modified the natural history of HIV infection. At the beginning of the cART era the objective was focused on HIV-1-associated mortality and morbidity, but as this objective was accomplished other issues emerged,...

  • An Investigation of the Determinants of Adherence to Highly Active Anti-Retroviral Therapy (HAART) in Aboriginal Men in the Downtown Eastside (DTES) of Vancouver. Chongo, Meck; Lavoie, Josée G.; Hoffman, Ross; Shubair, Mamdouh // Canadian Journal of Aboriginal Community-Based HIV/AIDS Research;Winter2011, Vol. 4, p32 

    The eradication of HIV is not yet possible; therefore persons undergoing treatment must take highly active antiretroviral therapy (HAART) regularly. In British Columbia (BC), antiretrovirals are distributed at no cost but the HIV-related annual mortality rate stands at 9% (Vancouver Native Heath...

  • Does antiretroviral therapy for HIV reduce the risk of developing multiple sclerosis? van der Kop, Mia L. // Journal of Neurology, Neurosurgery & Psychiatry;Jan2015, Vol. 86 Issue 1, p3 

    The article presents a case study that examines the association of HIV and its treatment with antiretroviral therapy (ART) on multiple sclerosis (MS). Topics discussed include use of data of HIV patients between 1999 and 2011 followed up with records of MS, authors of the study showing that the...

  • Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc. Borm, Katharina; Jakobsen, Martin R.; Cashin, Kieran; Flynn, Jacqueline K.; Ellenberg, Paula; Ostergaard, Lars; Lee, Benhur; Churchill, Melissa J.; Roche, Michael; Gorry, Paul R. // Retrovirology;11/3/2016, Vol. 13, p1 

    Background: Entry of human immunodeficiency virus type 1 (HIV-1) into cells involves the interaction of the viral gp120 envelope glycoproteins (Env) with cellular CD4 and a secondary coreceptor, which is typically one of the chemokine receptors CCR5 or CXCR4. CCR5-using (R5) HIV-1 strains that...

  • Efficacy of 1998 Vs 2006 First-Line Antiretroviral Regimens for HIV Infection: An Ordinary Clinics Retrospective Investigation. Parruti, Giustino; Polilli, Ennio; De Socio, Giuseppe Vittorio; Sozio, Federica; Marconi, Patrizia; Soddu, Viviana; Dalessandro, Margherita; Celesia, Benedetto Maurizio; Pellicanò, Giovanni; Madeddu, Giordano; Vecchiet, Jacopo; Masi, Francesco Di; Mazzotta, Elena; Ursini, Tamara; Martinelli, Canio; Vitiello, Paola; Bonfanti, Paolo; Nigro, Luciano; Mura, Maria Stella; Antinori, Andrea // Journal of Antivirals & Antiretrovirals;2012, Vol. 4 Issue 2, p32 

    Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART regimens in unselected patients treated in...

  • FACTORS INFLUENCING HAART ADHERENCE AMONG PRIVATE HEALTH CARE SECTOR PATIENTS IN A SUBURB OF THE ETHEKWINI METRO. Naidoo, Panjasaram // African Journal of Primary Health Care & Family Medicine;2009, Vol. 1 Issue 1, p28 

    Background: The advent of highly active antiretroviral therapy (HAART) ushered in a new era in the management of the AIDS pandemic with new drugs, new strategies, new vigour from treating clinicians and enthusiasm on the part of their patients. What soon became evident, however, was the vital...

  • Provision of Antiretroviral Therapy for HIV-Positive TB Patients -- 19 Countries, Sub-Saharan Africa, 2009-2013. Dokubo, E. Kainne; Baddeley, Annabel; Pathmanathan, Ishani; Coggin, William; Firth, Jacqueline; Getahun, Haileyesus; Kaplan, Jonathan; Date, Anand // MMWR: Morbidity & Mortality Weekly Report;11/28/2014, Vol. 63 Issue 47, p1104 

    The article discusses research which examined the progress in provision of antiretroviral therapy (ART) to patients with human immunodeficiency virus (HIV) infections and tuberculosis (TB) in sub-Saharan African countries in 2009-2013. Topics covered include the increase in ART coverage among...

  • Predictors of immunological failure and determinants of suboptimal CD4 testing among adults with HIV on first-line antiretroviral therapy in Andhra Pradesh, India, 2008-2011. Allama, Ramesh R.; Murhekar, Manoj V.; Bhatnagar, Tarun; Uthappa, Chengappa K.; Nalini, C.; Rewari, B. B.; Mehendale, Sanjay M. // Transactions of the Royal Society of Tropical Medicine & Hygiene;May2015, Vol. 109 Issue 5, p325 

    Background: Failure of first-line antiretroviral therapy (ART) results in high morbidity and mortality. We identified the predictors of immunological failure and suboptimal CD4 testing among adult people living with HIV (PLHIV) initiated on first-line ART. Methods: The cohort of PLHIV aged >15...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics