Haemorrhagic cystitis due to BK virus in a child with ALL on standard chemotherapy without stem cell transplant

Samin Alavi; Mohammad Kaji Yazdi; Mahmoud Parvin; Farahnaz Zohrehbandian; Roxana Azma
October 2013
Ecancermedicalscience;2013, Vol. 7 Issue 334-360, p1
Academic Journal
The BK virus (BKV) is a nonenveloped double-stranded DNA virus of the polyomavirus family that primarily affects immunocompromised people. BKV infects humans at an early age. Initial infections with BKV are mainly asymptomatic and usually remain latent in the brain, peripheral blood, kidneys, and urothelium. Following the primary infection, viruses persist indefinitely as 'latent' infections of the kidney and urinary system because the virus is urotheliotropic. Reactivation of the virus infections occurs in individuals with severe immunosuppression states such as kidney and stem cell transplantation and rarely in pregnancy. In this line, BKV has been implicated as a common cause of lateonset haemorrhagic cystitis (HC) in patients who have undergone stem cell transplantation. In contrast, reports of BKV-associated diseases in nontransplant paediatric patients are almost exclusively in patients with human immunodeficiency virus infection. Herein, we report the first case of a child with acute lymphoblastic leukaemia who developed BKV-associated HC without receiving stem cell transplantation while on standard maintenance chemotherapy


Related Articles

  • Aspergilosis Broncopulmonar Invasiva y Respuesta a Tratamiento Antimicótico. Vázquez Tsuji, Oscar; Félix Bermúdez, Georgina Elizabeth; Campos Rivera, Teresita // Revista de Enfermedades Infecciosas en Pediatria;jul-sep2013, Vol. 26 Issue 105, p327 

    No abstract available.

  • Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Leukemia following Orthotopic Cardiac Transplantation. Lin, Richard J.; Larson, Richard A.; van Besien, Koen; Rich, Elizabeth S. // Case Reports in Hematology;2013, p1 

    Therapy-related myeloid neoplasm (t-MN) is a subtype of acute myeloid leukemia with adverse cytogenetics and poor overall prognosis despite intensive induction chemotherapy and allogeneic hematopoietic cell transplantation (allo-HCT). It is increasingly recognized as a late complication of...

  • Impact of T cell selection methods in the success of clinical adoptive immunotherapy. Ramírez, Natalia; Beloki, Lorea; Ciaúrriz, Miriam; Rodríguez-Calvillo, Mercedes; Escors, David; Mansilla, Cristina; Bandrés, Eva; Olavarría, Eduardo // Cellular & Molecular Life Sciences;Apr2014, Vol. 71 Issue 7, p1211 

    Chemotherapy and/or radiotherapy regular regimens used for conditioning of recipients of hematopoietic stem cell transplantation (SCT) induce a period of transient profound immunosuppression. The onset of a competent immunological response, such as the appearance of viral-specific T cells, is...

  • Antineoplastics/immunosuppressants.  // Reactions Weekly;11/10/2007, Issue 1177, p6 

    The article describes a case of haemmorhagic cystitis induced by antineoplastics/immunosuppressants, namely, basiliximab, amsacrine and ciclosporin. A 24-year-old man received the drugs for graft-versus-host-disease following an allogeneic stem cell transplantation. It describes the symptoms...

  • IN THIS ISSUE.  // JNCI: Journal of the National Cancer Institute;Jan2012, Vol. 104 Issue 1, p1 

    An introduction to the journal is presented including an editorial on the use of high-dose chemotherapy with autologous stem cell transplantation for follicular lymphoma, one on accelerated partial breast irradiation using brachytherapy, and another on associations between high soy and legume...

  • Use of Filgrastim for Stem Cell Mobilisation and Transplantation in High-Dose Cancer Chemotherapy. Anderlini, P.; Champlin, R. // Drugs;2002 Supplement 1, Vol. 62 Issue 9, p79 

    Myeloablative or high-dose chemotherapy regimens utilise doses that are significantly greater than those used in standard treatments. The neutropenia caused by these high-dose therapies can be associated with an increased incidence of bacterial and fungal infections and remains an important...

  • Hemophagocytic lymphohistiocytosis: review of etiologies and management. George, Melissa R. // Journal of Blood Medicine;2014, Vol. 6, p69 

    Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening conditions featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH is often triggered by infection. Familial forms result from genetic defects in natural killer cells...

  • Computed Tomography Findings of Human Polyomavirus BK (BKV)-Associated Cystitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients. Schulze, M.; Beck, R.; Igney, A.; Vogel, M.; Maksimovic, O.; Claussen, C. D.; Faul, C.; Horger, M. // Acta Radiologica;Dec2008, Vol. 49 Issue 10, p1187 

    Background: Over 70% of the general population worldwide is positive for antibodies against polyomavirus hominis type 1 (BKV). Polyomavirus can be reactivated in immunocompromised patients and thereby induce urogenital tract infection, including cystitis. Purpose: To describe the computed...

  • Late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation in children. Kondo, M; Kojima, S; Kato, K; Matsuyama, T // Bone Marrow Transplantation;11/15/98, Vol. 22 Issue 10, p995 

    We analyzed the incidence, complications, and risk factors for late-onset hemorrhagic cystitis (HC) in 256 children undergoing hematopoietic stem cell transplantation (HSCT). Twenty-six recipients (10.2%) developed late-onset HC between 3 and 270 days (median, 33 days) after HSCT. In most...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics