The Impact of HIV on the Usefulness of Sputum Smears for the Diagnosis of Tuberculosis

Long, Richard; Scalcini, Marcella; Manfreda, Jure; Jean-Baptiste, Michel; Herchfield, Earl
October 1991
American Journal of Public Health;Oct91, Vol. 81 Issue 10, p1326
Academic Journal
In a developing country, 289 patients were examined for active pulmonary mycobacterial disease (sputum smear and culture) and HIV infection (serology) to compare the sensitivity and positive predictive value of sputum smears for diagnosing pulmonary tuberculosis in patients with and without antibodies to HIV. Seventy-nine percent of HIV-seronegative vs 66% of HIV-seropositive patients with positive cultures for Mycobacterium tuberculosis were smear positive (P < .05), and a positive sputum smear predicted the presence of M. tuberculosis in 90% of HIV seronegative vs 80% of HIV seropositive patients (P < .05). In our opinion, HIV did not significantly compromise the diagnostic utility of the sputum smear.


Related Articles

  • Poor concordance between interferon-γ release assays and tuberculin skin tests in diagnosis of latent tuberculosis infection among HIV-infected individuals. Talati, Naasha J.; Seybold, Ulrich; Humphrey, Bianca; Aina, Abiola; Tapia, Jane; Weinfurter, Paul; Albalak, Rachel; Blumberg, Henry M. // BMC Infectious Diseases;2009, Vol. 9 Issue 1, Special section p1 

    Background: A new generation of diagnostic tests, the interferon-γ release assays (IGRAs), have been developed for the detection of latent tuberculosis infection (LTBI). Limited data are available on their use in HIV-infected persons. Methods: A cross-sectional study was carried out at 2 HIV...

  • Nucleic Acid Amplification Tests for Diagnosis of Smear- Negative TB in a High HIV-Prevalence Setting: A Prospective Cohort Study. Davis, J. Lucian; Huang, Laurence; Worodria, William; Masur, Henry; Cattamanchi, Adithya; Huber, Charles; Miller, Cecily; Conville, Patricia S.; Murray, Patrick; Kovacs, Joseph A. // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. Few studies have evaluated the clinical impact of these tests in...

  • Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study. Kaforou, Myrsini; Wright, Victoria J.; Oni, Tolu; French, Neil; Anderson, Suzanne T.; Bangani, Nonzwakazi; Banwell, Claire M.; Brent, Andrew J.; Crampin, Amelia C.; Dockrell, Hazel M.; Eley, Brian; Heyderman, Robert S.; Hibberd, Martin L.; Kern, Florian; Langford, Paul R.; Ling, Ling; Mendelson, Marc; Ottenhoff, Tom H.; Zgambo, Femia; Wilkinson, Robert J. // PLoS Medicine;Oct2013, Vol. 10 Issue 10, p1 

    : Using a microarray-based approach, Michael Levin and colleagues develop a disease risk score to distinguish active from latent tuberculosis, as well as tuberculosis from other diseases, using whole blood samples. Please see later in the article for the Editors' Summary

  • Human Tuberculosis due to Mycobacterium bovis in the United States, 1995-2005. Hlavsa, Michele C.; Moonan, Patrick K.; Cowan, Lauren S.; Navin, Thomas R.; Kammerer, J. Steve; Morlock, Glenn P.; Crawford, Jack T.; LoBue, Philip A. // Clinical Infectious Diseases;7/15/2008, Vol. 47 Issue 2, p168 

    Background. Understanding the epidemiology of human Mycobacterium bovis tuberculosis (TB) in the United States is imperative; this disease can be foodborne or airborne, and current US control strategies are focused on TB due to Mycobacterium tuberculosis and airborne transmission. The National...

  • The usefulness of PCR assay in diagnosing disseminated mycobacterial infection in AIDS patients. Gazzola, L.; Zanini, F.; Zerbi, P.; Franzetti, F.; Gori, A. // European Journal of Clinical Microbiology & Infectious Diseases;Feb2008, Vol. 27 Issue 2, p163 

    The article presents a research which evaluates the usefulness of polymerase chain reaction (PCR) assay in diagnosing disseminated mycobacterial infection (DMI) with AIDS patients. Under the study, 71 blood samples from 65 patients were analysed by both culture and PCR assay, of which 15 were...

  • Mycobacterium kansasii: a cause of treatable pulmonary disease associated with advanced human immunodeficiency virus (HIV) infection. Levine, Beth; Chaisson, Richard E.; Levine, B; Chaisson, R E // Annals of Internal Medicine;5/15/91, Vol. 114 Issue 10, p861 

    Objective: To assess the clinical features and response to therapy of Mycobacterium kansasii infection in patients with human immunodeficiency virus (HIV) infection.Design: We reviewed the records of all patients with M. kansasii and HIV infection treated between...

  • Correlation of Mycobacterium Tuberculosis Specific and Non-Specific Quantitative Th1 T-Cell Responses with Bacillary Load in a High Burden Setting. Theron, Grant; Peter, Jonny; Lenders, Laura; Zyl-Smit, Richard van; Meldau, Richard; Govender, Ureshnie; Dheda, Keertan // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    Background: Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We hypothesised that, in a HIV-prevalent high burden...

  • Prospective study applying spoligotyping directly to DNA from sputum samples of patients suspected of having tuberculosis. Cafrune, Patricia Izquierdo; Possuelo, Lia Gonçalves; Ribeiro, Andrezza Wolowski; Ribeiro, Marta Osório; Unis, Gisela; Jarczewski, Carla Adriane; Rossetti, Maria Lúcia Rosa; Zaha, Arnaldo // Canadian Journal of Microbiology;Jul2009, Vol. 55 Issue 7, p895 

    A prospective study was designed to evaluate the clinical usefulness of spoligotyping applied directly to sputum samples. Patients suspected of having tuberculosis were recruited at the Hospital Sanatorio Partenon in Porto Alegre, Brazil. Of the 197 samples included in the analysis, 175 (88.8%)...

  • Clinical and laboratory observations of tuberculosis at a Mumbai (India) clinic. Gothi D; Joshi J M; Gothi, D; Joshi, J M // Postgraduate Medical Journal;Feb2004, Vol. 80 Issue 940, p97 

    Objectives: To study the positivity of sputum acid fast bacilli (AFB) smears in patients with pulmonary tuberculosis using 24 hour sputum collection. To detect HIV seropositivity in patients suffering from tuberculosis, and to analyse the pattern of tuberculosis disease in this...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics