TITLE

Transmission Fitness of Drug-Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral-Treated Population

AUTHOR(S)
Brown, Andrew J. Leigh; Frost, Simon D.W.; Mathews, W. Christopher; Dawson, Keith; Hellmann, Nicholas S.; Daar, Eric S.; Richman, Douglas D.; Little, Susan J.
PUB. DATE
February 2003
SOURCE
Journal of Infectious Diseases;2/15/2003, Vol. 187 Issue 4, p683
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only ∼20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.
ACCESSION #
9152476

 

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