Vitamin D Deficiency Rickets in Infants Presenting with Hypocalcaemic Convulsions

Cesur, Y.; Yuca, S. A.; Kaya, A.; Yilmaz, C.; Bay, A.
March 2013
West Indian Medical Journal;Mar2013, Vol. 62 Issue 3, p201
Academic Journal
Aim: Hypocalcaemia evaluation of the clinical, biochemical and radiological features of 91 infants with rickets who presented as hypocalcaemic convulsions. Subjects andMethods: Ninety-one hypocalcaemic infants who were brought to hospital with convulsion and diag-nosed with rickets related to vitamin D deficiency according to their clinical, biochemical and radio-logical features were retrospectively reviewed. Results: Mean values of the laboratory data were as follows: calcium 5.55 ± 0.79 mg/dL, phosphorus 4.77 ± 1.66 mg/dL, alkaline phosphatase 1525.5 ± 925.4 U/L and parathormone 256.8 ± 158.3 pg/mL. Serum 25-OH vitamin D levels were below normal (< 20 ng/mL) in 37 infants. Conclusion: Vitamin D deficiency should be considered in infants presenting with hypocalcaemia. To avoid complications such as convulsions, clinicians should give vitamin D supplementation to such infants.


Related Articles

  • Hypocalcemic Seizures in Breastfed Infants with Rickets Secondary to Severe Maternal Vitamin D Deficiency. Salama, Mostafa M.; El-Sakka, Abeer S. // Pakistan Journal of Biological Sciences;2010, Vol. 13 Issue 9, p437 

    This study was done to evaluate if nursing mothers of infants with rickets have vitamin D deficiency, and to evaluate the relationship between maternal vitamin D levels with hypocalcemic seizures in infants with rickets. We selected a cohort of breastfed infants with rickets. Infants were...

  • Circulating Insulin-like Growth Factor Binding Protein-4 (IGFBP-4) is not Regulated by Parathyroid Hormone and Vitamin D in vivo: Evidence from Children with Rickets. Bereket, Abdullah; Cesur, Yaşar; Özkan, Behzat; Adal, Erdal; Turan, Serap; Onan, Sertaç Hanedan; Döneray, Hakan; Akçay, Teoman; Haklar, Goncagül // Journal of Clinical Research in Pediatric Endocrinology;Mar2010, Vol. 2 Issue 1, p17 

    Objective: Insulin-like growth factor binding protein-4 (IGFBP-4), inhibits IGF actions under a variety of experimental conditions. Parathyroid hormone (PTH), 1.25-hydroxy(OH)vitamin D, IGF-I, IGF-II and transforming growth factor (TGF)-β are the major regulators of IGFBP-4 production in...

  • Successful Therapy of Vitamin D-Dependant Rickets in a Kitten.  // Journal of the American Animal Hospital Association;Jul2011, Vol. 47 Issue 4, p290 

    The article presents a case study of a 7-month-old kitten with vitamin D-dependent rickets. Based on diagnostic testing, the kitten had hypocalcemia, low ionized calcium and elevated intact parathyroid hormone concentration. Upon radiographic evaluation, it was found that the kitten has...

  • Vitamin D - Dependent Rickets, Type II Case Report. Azemi, Mehmedali; Berisha, Majlinda; Ismaili-Jaha, Vlora; Kolgeci, Selim; Hoxha, Rina; Grajçevci-Uka, Violeta; Hoxha-Kamberi, Teuta // Materia Socio Medica;Feb2014, Vol. 26 Issue 1, p68 

    Aim: The aim of this work the report of one case with vitamin D-dependent rickets, type II. Methods: Diagnosis has been established based on anamnesis, physical examination, laboratory findings and radiological examination. Results: A female child (age 25 months) has been hospitalized due to...

  • Vitamin D-Dependent Rickets Type 1: A Rare, but Treatable, Cause of Severe Hypotonia in Infancy. Yan, Yun; Calikoglu, Ali S.; Jain, Nina // Journal of Child Neurology;Dec2011, Vol. 26 Issue 12, p1571 

    Vitamin D-dependent rickets type 1 is an autosomal recessive disorder caused by an inactivating mutation of the 25-hydroxyvitamin-D-1α-hydroxylase (CYP27B1) gene. Clinical presentation is characterized by early onset of severe rickets and can include severe hypotonia. Here, we report a...

  • Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. D Haarburger // Journal of Clinical Pathology;Jun2009, Vol. 62 Issue 6, p567 

    AIM: The aim of this study was to test the hypothesis that vitamin D deficiency is associated with abnormal levels of calcium and parathyroid hormone (PTH). METHODS: Vitamin D requests at a tertiary hospital in South Africa over 2 years were retrospectively analysed along with calcium and PTH...

  • Vitamin D Deficiency in Children and Adolescents with Type 1 Diabetes. Mutlu, Ajda; Mutlu, Gül Yeşiltepe; Özsu, Elif; Çizmecioğlu, Filiz Mine; Hatun, Şükrü // Journal of Clinical Research in Pediatric Endocrinology;Dec2011, Vol. 3 Issue 4, p179 

    Objective: To investigate the frequency and effects of vitamin D deficiency in children with type 1 diabetes (T1D) in a region which is known to have a high rate of vitamin D deficiency among adolescents. Methods: In this prospective cross-sectional study, 120 children and adolescents with T1D...

  • Dose-Dependent Short-Term Effects of Single High Doses of Oral Vitamin D on Bone Turnover Markers. Rossini, Maurizio; Adami, Silvano; Viapiana, Ombretta; Fracassi, Elena; Idolazzi, Luca; Povino, Maria; Gatti, Davide // Calcified Tissue International;Dec2012, Vol. 91 Issue 6, p365 

    We investigated the short-term effects on bone turnover markers of high doses of vitamin D in order to identify what initial therapeutic dose can be safely administered in vitamin D-deficient subjects. Thirty-seven elderly subjects [mean age 75 ± 3 (SD) years] were consecutively randomized to...

  • Is Vitamin D Deficiency associated with Non Specific Musculoskeletal Pain? Abbasi, Mahnaz; Hashemipour, Sima; Hajmanuchehri, Fatemeh; Kazemifar, Amir Mohammad // Global Journal of Health Science;Jan2013, Vol. 5 Issue 1, p107 

    Backgrounds: Vitamin D deficiency is common worldwide, including Iran. It has been suggested that vitamin D deficiency is associated with non-specific musculoskeletal pain. The aim of this study is evaluation of the association of musculoskeletal pain with vitamin D deficiency and the response...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics