TITLE

Long- Term Outcomes of Drug- Eluting Stent Therapy for In- Stent Restenosis Versus De Novo Lesions

AUTHOR(S)
GAO, ZHAN; XU, BO; YANG, YUE‐JIN; YUAN, JIN‐QING; CHEN, JUE; CHEN, JI‐LIN; QIAO, SHU‐BIN; WU, YONG‐JIAN; YAN, HONG‐BIN; GAO, RUN‐LIN
PUB. DATE
December 2013
SOURCE
Journal of Interventional Cardiology;Dec2013, Vol. 26 Issue 6, p550
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background Drug-eluting stents (DES) are currently the most popular treatment modality for restenosis in bare metal stents and DES. This study compares risks of adverse cardiovascular events between DES-treated in-stent restenosis (ISR) and de novo lesions, an area that has not been systematically studied thus far. Methods and Results One thousand three hundred consecutive ISR patients were compared with 27,211 patients with de novo lesions who underwent DES treatment during the same period at the Fu Wai Hospital in Beijing. Angiographic success rate was similar between the ISR and de novo groups (98.0% vs. 98.2%; P = 0.61). Using logistic regression to derive the propensity score model, 1,266 matched patient pairs were compared. In this adjusted model, the rate of target lesion revascularization (TLR) was significantly higher in the ISR group (19.19% vs. 2.37%; P < 0.01) during an average 17-month follow-up, while rates of cardiac death and myocardial infarction (MI) were similar (0.71% vs. 0.79%; P = 0.93 and 3.48% vs. 1.26%; P = 0.13, respectively) between groups. In multivariate regression analysis, ISR was predictive of TLR, but not of cardiac death and MI. Conclusion Compared with those with de novo lesions, patients with ISR had a higher revascularization rate after DES treatment but no significant difference in rates of cardiac death and MI.
ACCESSION #
92728248

 

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