Cell Therapy of Refractory Crohn’s Disease

Knyazev, O. V.; Parfenov, A. I.; Shcherbakov, P. L.; Ruchkina, I. N.; Konoplyannikov, A. G.
November 2013
Bulletin of Experimental Biology & Medicine;Nov2013, Vol. 156 Issue 1, p139
Academic Journal
We analyzed medium-term efficiency and safety of biological therapy of Crohn’s disease, in particular transplantation of allogenic mesenchymal stromal bone marrow cells and anticytokine therapy with selective immunosuppressive agents. It was found that both methods of biological therapy of refractory Crohn’s disease resulted in clinical and in some cases endoscopic remission. In most cases, clinical remission was maintained without steroid hormone therapy. Thus, both methods produce comparable clinical results. It was concluded that transplantation of mesenchymal stromal bone marrow cells could be considered as a promising method in the therapy of refractory Crohn’s disease comparable by its efficiency with infliximab therapy.


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