TITLE

The Survival Benefits of Antiretroviral Therapy in South Africa

AUTHOR(S)
April, Michael D.; Wood, Robin; Berkowitz, Bethany K.; Paltiel, A. David; Anglaret, Xavier; Losina, Elena; Freedberg, Kenneth A.; Walensky, Rochelle P.
PUB. DATE
February 2014
SOURCE
Journal of Infectious Diseases;Feb2014, Vol. 209 Issue 4, p491
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. We sought to quantify the survival benefits attributable to antiretroviral therapy (ART) in South Africa since 2004.Methods. We used the Cost-Effectiveness of Preventing AIDS Complications–International model (CEPAC) to simulate 8 cohorts of human immunodeficiency virus (HIV)–infected patients initiating ART each year during 2004–2011. Model inputs included cohort-specific mean CD4+ T-cell count at ART initiation (112–178 cells/µL), 24-week ART suppressive efficacy (78%), second-line ART availability (2.4% of ART recipients), and cohort-specific 36-month retention rate (55%–71%). CEPAC simulated survival twice for each cohort, once with and once without ART. The sum of the products of per capita survival differences and the total numbers of persons initiating ART for each cohort yielded the total survival benefits.Results. Lifetime per capita survival benefits ranged from 9.3 to 10.2 life-years across the 8 cohorts. Total estimated population lifetime survival benefit for all persons starting ART during 2004–2011 was 21.7 million life-years, of which 2.8 million life-years (12.7%) had been realized by December 2012. By 2030, benefits reached 17.9 million life-years under current policies, 21.7 million life-years with universal second-line ART, 23.3 million life-years with increased linkage to care of eligible untreated patients, and 28.0 million life-years with both linkage to care and universal second-line ART.Conclusions. We found dramatic past and potential future survival benefits attributable to ART, justifying international support of ART rollout in South Africa.
ACCESSION #
94184499

 

Related Articles

  • A longitudinal study assessing differences in causes of death among housed and homeless people diagnosed with HIV in San Francisco. Hessol, Nancy A.; Eng, Monica; Vu, Annie; Pipkin, Sharon; Hsu, Ling C.; Scheer, Susan // BMC Public Health;11/1/2019, Vol. 19 Issue 1, p1 

    Background: San Francisco has implemented several programs addressing the needs of two large vulnerable populations: people living with HIV and those who are homeless. Assessment of these programs on health outcomes is paramount for reducing preventable deaths.Methods:...

  • Antiretroviral Use in Resource-Poor Settings: Modeling Its Impact.  // PLoS Medicine;Apr2006, Vol. 3 Issue 4, pe179 

    The article discusses Antiretroviral Therapy(ART) in the treatment of HIV/AIDS patients in resource-poor countries. The reduction in HIV mortality rate with ART access in affluent countries and the necessity of making rural Africa ART accessaible is discussed. A revelation of the study on...

  • Spectrum of opportunistic infections in hospitalized HIV-infected patients in Phnom Penh, Cambodia. Senya, Chhin; Mehta, Akanksha; Harwell, Joseph I.; Pugatch, David; Flanigan, Timothy; Mayer, Kenneth H. // International Journal of STD & AIDS;Jun2003, Vol. 14 Issue 6, p411 

    The aim of the study was to provide more comprehensive data on the clinical characteristics of hospitalized AIDS patients in Cambodia. Chart review of 381 HIV-infected patients admitted to a public hospital in Phnom Penh, Cambodia between December 1999 and May 2000 was performed. The in-hospital...

  • Correction: HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? null, null // PLoS ONE;Jan2015, Vol. 10 Issue 1, p1 

    No abstract available.

  • superinfection a changing picture. Duffin, Ross // HIV Australia;Jun-Aug2004, Vol. 3 Issue 4, p9 

    Discusses the impact of superinfection on an individual's HIV disease progression. Overview of several HIV superinfection cases in Australia; Frequency of the occurrence of superinfection; Recommended approach to prevent HIV superinfection.

  • Chapter 5: Treatment, care and support for people living with HIV.  // Report on the Global HIV/AIDS Epidemic: UNAIDS - 2004;1/1/2004, p99 

    Chapter 5 of the book "2004 Report on the global AIDS epidemic" is presented. It discusses the treatment and support given to people with HIV in different countries and the availability of antiretroviral therapy. It also highlights the manner of giving equitable antiretrovirals to men and women....

  • The Importance of Potency and Durability in HIV Patient Antiretroviral Therapy Preferences: A Telephone Survey. Sherer Jr., Renslow D.; Fath, Michael J.; Da Silva, Barbara A.; Nicolau, Ana-Maria; Miller, Nancy L. // AIDS Patient Care & STDs;Dec2005, Vol. 19 Issue 12, p794 

    Patients who were receiving or had received antiretroviral therapy (ART) participated in 45-minute telephone interviews to evaluate the importance of major treatment attributes. A Likert scale was used to quantify and rate the importance of 9 ART attributes. Trade-off exercises allowed...

  • Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy. Grund, Birgit; Baker, Jason V; Deeks, Steven G.; Wolfson, Julian; Wentworth, Deborah; Cozzi-Lepri, Alessandro; Cohen, Calvin J.; Phillips, Andrew; Lundgren, Jens D.; Neaton, James D.; null, null // PLoS ONE;5/12/2016, Vol. 11 Issue 5, p1 

    Background: Despite effective antiretroviral treatment (ART), HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers), perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk...

  • American Cities Lead the Way. Martin, Marsha A. // Human Rights;Spring2010, Vol. 37 Issue 2, p20 

    The article discusses the human immuno deficiency virus (HIV) testing initiatives taken by several U.S. cities and presents suggestions on planning a municipal HIV testing initiative. It is stated that to encourage all citizens between the ages of 14 and 84 to get tested for HIV, an energetic...

  • Trends in HIV testing, serial HIV prevalence and HIV incidence among people attending a Center for AIDS Prevention from 1988 to 2003. Hurtado, I.; Alastrue, I.; Ferreros, I.; del Amo, J.; Santos, C.; Tasa, T.; Hernández-Aguado, I.; Pérez-Hoyos, S. // Sexually Transmitted Infections;Feb2007, Vol. 83 Issue 1, p23 

    Aim: To analyse trends in HIV testing, serial HIV prevalence and HIV incidence among people who underwent voluntary testing in a Center for AIDS Prevention in Valencia, Spain. Methods: Open cohort study including all subjects who went to the Center for AIDS Prevention from 1988 to 2003....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics