TITLE

Progression of Chronic Hepatitis C to Liver Fibrosis and Cirrhosis in Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus

AUTHOR(S)
Martinez-Sierra, Carmen; Arizcorreta, Ana; Díaz, Fernando; Roldán, Rafael; Martín-Herrera, Leopoldo; Pérez-Guzmán, Eugenio; Girón-González, José A.
PUB. DATE
February 2003
SOURCE
Clinical Infectious Diseases;2/15/2003, Vol. 36 Issue 4, p491
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To evaluate the factors associated with the evolution of chronic hepatitis C in human immunodeficiency virus (HIV)-infected patients, a cross-sectional analysis of 41 HIV-infected patients with chronic hepatitis C (known as "HIV-HCV [hepatitis C virus]-coinfected patients") and a control group of patients with chronic hepatitis C who did not have HIV infection (known as "non-HIV-infected patients") was performed. The association of histological variables with demographic parameters, HCV load and genotype, HIV load, CD4[SUP+]T cell count, and response to highly active antiretroviral therapy (HAART) was evaluated. HIV-HCV-coinfected patients showed a significantly higher HCV load, more-advanced fibrosis, and a higher liver fibrosis progression rate (FPR) than did non-HIV-infected patients. A high HCV load and a low CD4[SUP+] T cell count were associated with a higher FPR. The immune response induced by HAART did not influence this progression. In conclusion, HIV-HCV-infected patients, mainly such patients with a high HCV load and an immunodepressed state, have a higher FPR. An independent effect of the immune response to HAART was not evident.
ACCESSION #
9424828

 

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