Kingman, Sharon
February 2014
BioWorld Today;2/6/2014, Vol. 25 Issue 25, p6
The article reports on a 2014 finding that links the therapeutic effect of the growth factor glial cell line-derived neurotrphic factor (GDNF) using the PINK1 model to mitochondrial degeneration in a disease model for Parkinson's disease.


Related Articles

  • UNEVEN RESULTS. Kingman, Sharon // BioWorld Today;2/6/2014, Vol. 25 Issue 25, p6 

    The article reports on a probe in 2014 on the action of glial cell line-derived neurotrophic factor (GDNF) on patients with Parkinson's disease using genetically modified Drosophilia flies and a gene encoding an activated form of the molecule Ret.

  • Adeno-Associated Virus Type 2 Vector-Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Induces Neuroprotection and Neuroregeneration in a Ubiquitin-Proteasome System Impairment Animal Model of Parkinson's Disease. Du, Yunlan; Zhang, Xiaojie; Tao, Qingqing; Chen, Sheng; Le, Weidong // Neurodegenerative Diseases;Jan2013, Vol. 11 Issue 3, p113 

    Background: The impairment of the ubiquitin-proteasome system (UPS) is a cellular mechanism underlying the neurodegenerative process in Parkinson's disease (PD). A mouse model induced by the selective proteasome inhibitor lactacystin targeting on substantia nigra has been demonstrated to be...

  • Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery. Drinkut, Anja; Tereshchenko, Yuliya; Schulz, Jörg B; Bähr, Mathias; Kügler, Sebastian // Molecular Therapy;Mar2012, Vol. 20 Issue 3, p534 

    Current gene therapy approaches for Parkinson's disease (PD) deliver neurotrophic factors like glial cell line-derived neurotrophic factor (GDNF) or neurturin via neuronal transgene expression. Since these potent signaling-inducing neurotrophic factors can be distributed through long-distance...

  • The Potential Neuroprotection Mechanism of GDNF in the 6-OHDA-Induced Cellular Models of Parkinson's Disease. Li, Feng; Wang, Meng; Zhu, Shuan; Li, Li; Xiong, Ye; Gao, Dian-Shuai // Cellular & Molecular Neurobiology;Oct2013, Vol. 33 Issue 7, p907 

    The glial cell line-derived neurotrophic factor (GDNF) potential as a therapeutic agent for the treatment of Parkinson's Disease (PD) has been extensively explored. However, the mechanism of the GDNF neuroprotective effects is still unclear. In this study, the neuroprotective mechanism of the...

  • GDNF Family Ligands: A Potential Future for Parkinson's Disease Therapy. Mickiewicz, Amanda L.; Kordower, Jeffrey H. // CNS & Neurological Disorders - Drug Targets;Sep2011, Vol. 10 Issue 6, p703 

    Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction that occurs secondary to loss of dopaminergic neurons in the nigrostriatal pathway. Current pharmacotherapies focus on the replacement of lost dopamine to alleviate disease symptoms. However,...

  • Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. Nadella, Rasajna; Voutilainen, Merja H.; Saarma, Mart; Gonzalez-Barrios, Juan A.; Leon-Chavez, Bertha A.; Dueñas Jiménez, Judith M.; Dueñas Jiménez, Sergio H.; Escobedo, Lourdes; Martinez-Fong, Daniel // Journal of Neuroinflammation;2014, Vol. 11 Issue 1, p215 

    Background The anti-inflammatory effect of the cerebral dopamine neurotrophic factor (CDNF) was shown recently in primary glial cell cultures, yet such effect remains unknown both in vivo and in 6-hydroxydopamine (6-OHDA) models of Parkinson's disease (PD). We addressed this issue by performing...

  • Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. Praveen Meka, Durga; Müller-Rischart, Anne Kathrin; Nidadavolu, Prakash; Mohammadi, Behnam; Motori, Elisa; Ponna, Srinivas Kumar; Aboutalebi, Helia; Bassal, Mahmoud; Annamneedi, Anil; Finckh, Barbara; Miesbauer, Margit; Rotermund, Natalie; Lohr, Christian; Tatzelt, Jörg; Winklhofer, Konstanze F.; Kramer, Edgar R. // Journal of Clinical Investigation;May2015, Vol. 125 Issue 5, p1873 

    Parkin and the glial cell line-derived neurotrophic factor (GDNF) receptor RET have both been independently linked to the dopaminergic neuron degeneration that underlies Parkinson's disease (PD). In the present study, we demonstrate that there is genetic crosstalk between parkin and the receptor...

  • Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety. Kotyuk, Eszter; Keszler, Gergely; Nemeth, Nora; Ronai, Zsolt; Sasvari-Szekely, Maria; Szekely, Anna // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for dopaminergic neurons with promising therapeutic potential in Parkinson's disease. A few association analyses between GDNF gene polymorphisms and psychiatric disorders such as schizophrenia, attention deficit...

  • GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson's Disease Mouse Model. Zhao, Yuling; Haney, Matthew J.; Gupta, Richa; Bohnsack, John P.; He, Zhijian; Kabanov, Alexander V.; Batrakova, Elena V. // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    The pathobiology of Parkinson's disease (PD) is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) projecting to the striatum. Currently, there are no treatments that can halt or reverse the course of PD; only palliative therapies, such as replacement...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics