Enhancing Induced Pluripotent Stem CellModels of Schizophrenia

Wright, Rebecca; Réthelyi, János M.; Gage, Fred H.
March 2014
JAMA Psychiatry;Mar2014, Vol. 71 Issue 3, p334
Academic Journal
The article discusses issues related to enhancing induced pluripotent stem cell (IPSC) models of schizophrenia. It cites several ways to enhance future IPSC models of schizophrenia to reduce variability between studies. It also examines the generation of specific, homogeneous neuronal populations from IPSCs and the generation of IPSC models based on patient subgroups.


Related Articles

  • C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Di Stefano, Bruno; Sardina, Jose Luis; van Oevelen, Chris; Collombet, Samuel; Kallin, Eric M.; Vicent, Guillermo P.; Lu, Jun; Thieffry, Denis; Beato, Miguel; Graf, Thomas // Nature;2/13/2014, Vol. 506 Issue 7487, p235 

    CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called...

  • Stem cells: Multiple routes to pluripotency. Baumann, Kim // Nature Reviews Molecular Cell Biology;Jan2015, Vol. 16 Issue 1, p1 

    The article discusses the different routes of reprogramming somatic cells into pluripotent stem cells. It cites various studies that provide a comprehensive analysis of the molecular changes in induced pluripotent stem cells in multiple states. It reveals the possibility of creating artificial...

  • Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming. Rao, Radhika Arasala; Dhele, Narendra; Cheemadan, Sabna; Ketkar, Alhad; Jayandharan, Giridhara R.; Palakodeti, Dasaradhi; Rampalli, Shravanti // Scientific Reports;2/6/2015, p8229 

    Factor induced reprogramming of fibroblasts is an orchestrated but inefficient process. At the epigenetic level, it results in drastic chromatin changes to erase the existing somatic 'memory' and to establish the pluripotent state. Accordingly, alterations of chromatin regulators including Ezh2...

  • Stem cells: Multiple routes to pluripotency. Baumann, Kim // Nature Reviews Genetics;Feb2015, Vol. 16 Issue 2, p67 

    The article highlights a study reporting extensive transcriptomic, epigenomic and proteomic analyses of reprogramming, revealing the existence of several reprogramming routes and showing that induced pluripotent stem (iPS) cells exist in multiple unique cell states. The studies provide a...

  • Melanocytes Derived from Transgene-Free Human Induced Pluripotent Stem Cells. Jones, Jennifer C; Sabatini, Karen; Liao, Xiaoyan; Tran, Ha T; Lynch, Candace L; Morey, Robert E; Glenn-Pratola, Victoria; Boscolo, Francesca S; Yang, Qinghong; Parast, Mana M; Liu, Ying; Peterson, Suzanne E; Laurent, Louise C; Loring, Jeanne F; Wang, Yu-Chieh // Journal of Investigative Dermatology;Aug2013, Vol. 133 Issue 8, p2104 

    A letter to the editor is presented on the topic related to transgene-free human induced pluripotent stem cells (hiPSC) derived melanocytes.

  • Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application. Dash, Biraja C.; Zhengxin Jiang; Suh, Carol; Yibing Qyang // Biochemical Journal;1/15/2015, Vol. 465 Issue 2, p185 

    Vascular smooth muscle cells (VSMCs) play a major role in the pathophysiology of cardiovascular diseases. The advent of induced pluripotent stem cell (iPSC) technology and the capability of differentiating into virtually every cell type in the human body make this field a ray of hope for...

  • Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients. Robicsek, O; Karry, R; Petit, I; Salman-Kesner, N; Müller, F-J; Klein, E; Aberdam, D; Ben-Shachar, D // Molecular Psychiatry;Oct2013, Vol. 18 Issue 10, p1067 

    One of the prevailing hypotheses suggests schizophrenia as a neurodevelopmental disorder, involving dysfunction of dopaminergic and glutamatergic systems. Accumulating evidence suggests mitochondria as an additional pathological factor in schizophrenia. An attractive model to study processes...

  • Synaptic dysregulation in a human iPS cell model of mental disorders. Wen, Zhexing; Yoritomo, Nadine; Kaibuchi, Kozo; Zou, Jizhong; Cheng, Linzhao; Ross, Christopher A.; Margolis, Russell L.; Chen, Gong; Song, Hongjun; Ming, Guo-li; Nguyen, Ha Nam; Guo, Ziyuan; Lalli, Matthew A.; Guzman, Elmer; Kosik, Kenneth S.; Wang, Xinyuan; Su, Yijing; Kim, Nam-Shik; Yoon, Ki-Jun; Zhang, Ce // Nature;11/20/2014, Vol. 515 Issue 7527, p414 

    Dysregulated neurodevelopment with altered structural and functional connectivity is believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the major hypothesis for the biological basis of schizophrenia. Although this hypothesis has gained indirect support from...

  • MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived Neurons. Larimore, Jennifer; Ryder, Pearl V.; Kim, Kun-Yong; Ambrose, L. Alex; Chapleau, Christopher; Calfa, Gaston; Gross, Christina; Bassell, Gary J.; Pozzo-Miller, Lucas; Smith, Yoland; Talbot, Konrad; Park, In-Hyun; Faundez, Victor // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affect the expression of genes encoding the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics