TITLE

Systematic Review into Diagnostics for Post-Kala-Azar Dermal Leishmaniasis (PKDL)

AUTHOR(S)
Adams, Emily R.; Versteeg, Inge; Leeflang, Mariska M. G.
PUB. DATE
January 2013
SOURCE
Journal of Tropical Medicine (16879686);2013, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Identification of post-kala-azar dermal leishmaniasis (PKDL) is important due to the long and toxic treatment and the fact that PKDL patients may serve as a reservoir for visceral leishmaniasis (VL). We summarized the published literature about the accuracy of diagnostic tests for PKDL. We searched Medline for eligible studies investigating the diagnostic accuracy of any test for PKDL. Study quality was assessed using QUADAS-2. Data were extracted from 21 articles including 43 separate studies. Twenty-seven studies evaluated serological tests (rK39 dipstick, ELISA, DAT, and leishmanin tests), six studies molecular tests, eight microscopy, and two cultures. Only a few of these studies reported a valid estimate of diagnostic accuracy, as most were case-control designs or used a reference standard with low sensitivity. The included studies were very heterogeneous, for example, due to a large variety of reference standards used. Hence, no summary estimates of sensitivity or specificity could be made. We recommend well-designed diagnostic accuracy trials that evaluate, side-by-side, all currently available diagnostics, including clinical symptoms, serological, antigen, molecular, and parasitological tests and possible use of statistical modelling to evaluate diagnostics when there is no suitable gold standard.
ACCESSION #
95044672

 

Related Articles

  • CANINE VISCERAL LEISHMANIASIS: STUDY OF METHODS FOR THE DETECTION OF IgG IN SERUM AND ELUATE SAMPLES. Figeiredo, Fabiano B.; Madeira, Maria F.; Nascimento, Lílian D.; Abrantes, Tuanne R.; Mouta-Confort, Eliame; Passos, Sonia Regina L.; Schubach, Tânia Maria P. // Revista do Instituto de Medicina Tropical de Sao Paulo;jul2010, Vol. 52 Issue 4, p193 

    The Brazilian Ministry of Health recommends the culling and euthanasia of dogs with a positive serological test for canine visceral leishmaniasis (CVL). In the Municipality of Rio de Janeiro, the technique used for the diagnosis of CVL is the indirect fluorescent antibody test (IFAT), using...

  • Inaccuracy of Enzyme-Linked Immunosorbent Assay Using Soluble and Recombinant Antigens to Detect Asymptomatic Infection by Leishmania infantum. Moreno, Elizabeth Castro; Gonçalves, Andréa Vieira; Chaves, Anderson Vieira; Melo, Maria Norma; Lambertucci, José Roberto; Andrade, Antero Silva Ribeiro; Deborah Negrão-Corrêa; Antunes, Carlos Mauricio de Figueiredo; Carneiro, Mariângela // PLoS Neglected Tropical Diseases;Oct2009, Vol. 3 Issue 10, p1 

    Background: One of the most important drawbacks in visceral leishmaniasis (VL) population studies is the difficulty of diagnosing asymptomatic carriers. The aim of this study, conducted in an urban area in the Southeast of Brazil, was to evaluate the performance of serology to identify...

  • Evaluation of Change in Canine Diagnosis Protocol Adopted by the Visceral Leishmaniasis Control Program in Brazil and a New Proposal for Diagnosis. Coura-Vital, Wendel; Ker, Henrique Gama; Roatt, Bruno Mendes; Aguiar-Soares, Rodrigo Dian Oliveira; Leal, Gleisiane Gomes de Almeida; Moreira, Nádia das Dores; Oliveira, Laser Antônio Machado; de Menezes Machado, Evandro Marques; Morais, Maria Helena Franco; Corrêa-Oliveira, Rodrigo; Carneiro, Mariângela; Reis, Alexandre Barbosa // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    The techniques used for diagnosis of canine visceral leishmaniasis (CVL) in Brazil ELISA and IFAT have been extensively questioned because of the accuracy of these tests. A recent change in the diagnosis protocol excluded IFAT and included the Dual-Path Platform (DPP). We evaluated the...

  • Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil Caldas, A.J.M.; Costa, J.M.L.; Silva, A.A.M.; Vinhas, V.; Barral, A. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Jan2002, Vol. 96 Issue 1, p21 

    Various factors have been associated with a predisposition to the development of clinical American visceral leishmaniasis (AVL). However, little information is available about the factors that predispose to asymptomatic infection. To identify the risk factors associated with asymptomatic...

  • Evaluation of enzyme-linked immunosorbent assay in the diagnosis of kala-azar in Malda district... Gupta, Suman; Smith, Jeanette M. // JAMA: Journal of the American Medical Association;6/22/94-6/29/94, Vol. 271 Issue 24, p1890c 

    Evaluates the usefulness of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of kala-azar. Detection of antileishmanial antibodies; Antigen requirement per test; Cross-reactivity of sera from patients with other parasitic diseases; Results of follow-up monitoring.

  • Molecular and serological evidence for the circulation of the tick symbiont Midichloria (Rickettsiales: Midichloriaceae) in different mammalian species. Bazzocchi, Chiara; Mariconti, Mara; Sassera, Davide; Rinaldi, Laura; Martin, Elena; Cringoli, Giuseppe; Urbanelli, Sandra; Genchi, Claudio; Bandi, Claudio; Epis, Sara // Parasites & Vectors;2013, Vol. 6 Issue 1, p1 

    Background The Midichloriaceae is a novel family of the order Rickettsiales, that encompasses intracellular bacteria associated with hard ticks (Ixodidae) and other arthropods. The most intensively investigated member of this family is Midichloria mitochondrii, a symbiotic bacterium of the sheep...

  • Automated Strategy for Immuno-MS Sample Preparation. Field, Brian // R&D Magazine;Feb2014, Vol. 56 Issue 1, p14 

    The article focuses on the use of immuno-purification with mass spectrometry (immuno-MS) as an alternative diagnostic testing for protein isoform detection. Topics include the enzyme-linked immunosorbent assays (ELISA) as the traditional antibody-based diagnostic tests, trypsin digestion, and...

  • Development and comparative evaluation of two antigen detection tests for Visceral Leishmaniasis. Vallur, Aarthy C.; Tutterrow, Yeung L.; Mohamath, Raodoh; Pattabhi, Sowmya; Hailu, Asrat; Abdoun, Asim O.; Ahmed, Abdalla E.; Mukhtar, Maowia; Salam, Md. Abdus; Almeida, Meirielly Lima; Almeida, Roque P.; Mondal, Dinesh; Albertini, Audrey; Ghalib, Hashim; Duthie, Malcolm S.; Reed, Steven G. // BMC Infectious Diseases;9/23/2015, Vol. 15 Issue 1, p1 

    Background: Visceral leishmaniasis (VL) can be fatal without timely diagnosis and treatment. Treatment efficacies vary due to drug resistance, drug toxicity and co-morbidities. It is important to monitor treatment responsiveness to confirm cure and curtail relapse. Currently,...

  • LABORATORY DIAGNOSIS AND CLINICAL SIGNS OF CANINE VISCERAL LEISHMANIASIS IN DOGS EXAMINED AT THE CENTER FOR ZOONOSIS CONTROL IN CAMPO GRANDE - MS, BRAZIL. Cunha, Rodrigo Casquero; Andreotti, Renato; Araujo e Silva, Elaine; Pereira, Elisângela; Sato, Tayra; Thomaz-Soccol, Vanete // Archives of Veterinary Science;2012, Vol. 17 Issue 4, p17 

    Visceral leishmaniasis is a type of zoonosis caused by several Leishmania species endemic to tropical, subtropical, and Mediterranean climate regions. Dogs are the primary source of infection in urban areas and can be symptomatic or asymptomatic. This study focused on the observation of clinical...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics