TITLE

Risk of Melanoma in People with HIV/AIDS in the Pre- and Post-HAART Eras: A Systematic Review and Meta-Analysis of Cohort Studies

AUTHOR(S)
Olsen, Catherine M.; Knight, Lani L.; Green, Adèle C.
PUB. DATE
April 2014
SOURCE
PLoS ONE;Apr2014, Vol. 9 Issue 4, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Following the introduction of highly active antiretroviral therapy (HAART) the risk of AIDS-defining cancers decreased but incidence of many non-AIDS-defining cancers has reportedly increased in those with HIV/AIDS. Whether melanoma risk has also changed in HIV/AIDS patients post-HAART is unknown and therefore we evaluated this in comparison with the risk before HAART. Design: Systematic review and meta-analysis. Methods: We searched Medline, Embase and ISI science citation index databases to April 2013. All cohort studies of patients diagnosed with HIV/AIDS that permitted quantitative assessment of the association with melanoma were eligible. Detailed quality assessment of eligible studies was conducted, focussing particularly on adjustment for ethnicity, a priori considered essential for an unbiased assessment of melanoma risk. Data were pooled using a random effects model. Results: From 288 articles, we identified 21 that met the inclusion criteria, 13 presenting data for the post-HAART era and 8 for the pre-HAART era. Post-HAART the pooled relative risk (pRR) for the association between HIV/AIDS and melanoma was 1.26 (95% CI, 0.97–1.64) and 1.50 (95% CI 1.12–2.01) among studies that accounted for ethnicity, with evidence of significant heterogeneity (P = 0.004, I2 = 55.5). Pre-HAART pRRs were 1.26 (95% CI 1.11–1.43; Phet = 0.82) and 1.28 (95% CI 1.10–1.49) among studies adjusted for ethnicity. Conclusions: People with HIV/AIDS remain at a significantly increased risk of developing melanoma in the post-HAART era. White skinned people with HIV/AIDS should be screened regularly and counselled against excessive sun exposure.
ACCESSION #
95819600

 

Related Articles

  • Retention in HIV Care between Testing and Treatment in Sub-Saharan Africa: A Systematic Review. Rosen, Sydney; Fox, Matthew P. // PLoS Medicine;Jul2011, Vol. 8 Issue 7, p1 

    Background: Improving the outcomes of HIV/AIDS treatment programs in resource-limited settings requires successful linkage of patients testing positive for HIV to pre-antiretroviral therapy (ART) care and retention in pre-ART care until ART initiation. We conducted a systematic review of pre-ART...

  • A systematic review of cohort studies of the quality of life in HIV/AIDS patients after antiretroviral therapy. Jin, Yantao; Liu, Zhibin; Wang, Xin; Liu, Huixin; Ding, Guowei; Su, Yingying; Zhu, Lin; Wang, Ning // International Journal of STD & AIDS;Oct2014, Vol. 25 Issue 11, p771 

    The aim of this paper was to review cohort studies that analyze changes in the quality of life of people living with HIV/AIDS. We searched the PubMed and EmBase databases from inception to December 2012 for primary cohort studies of the quality of life of people living with HIV/AIDS after...

  • Survival of HIV-Infected Adolescents on Antiretroviral Therapy in Uganda: Findings from a Nationally Representative Cohort in Uganda. Bakanda, Celestin; Birungi, Josephine; Mwesigwa, Robert; Nachega, Jean B.; Chan, Keith; Palmer, Alexis; Ford, Nathan; Mills, Edward J. // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    Background: Adolescents have been identified as a high-risk group for poor adherence to and defaulting from combination antiretroviral therapy (cART) care. However, data on outcomes for adolescents on cART in resource-limited settings remain scarce. Methods: We developed an observational study...

  • Anti-Retroviral Treatment Outcomes among Older Adults in Zomba District, Malawi. Negin, Joel; van Lettow, Monique; Semba, Medson; Martiniuk, Alexandra; Chan, Adrienne; Cumming, Robert G. // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Background: There are approximately 3 million people aged 50 and older in sub-Saharan Africa who are HIV-positive. Despite this, little is known about the characteristics of older adults who are on treatment and their treatment outcomes. Methods: A retrospective cohort analysis was performed...

  • Diabetes Mellitus Is an Independent Risk Factor for Colorectal Cancer. Sun, Lei; Yu, Shiying // Digestive Diseases & Sciences;Jun2012, Vol. 57 Issue 6, p1586 

    Background: Epidemiological studies have suggested positive associations between diabetes and colorectal cancer. However, the findings were inconsistent, especially regarding specific sex or cancer subsite. Aims: To conduct a systematic review with meta-analysis to examine the association of...

  • Risk of Cancer among Commercially Insured HIV-Infected Adults on Antiretroviral Therapy. Lee, Jeannette Y.; Dhakal, Ishwori; Casper, Corey; Noy, Ariela; Palefsky, Joel M.; Haigentz, Missak; Krown, Susan E.; Ambinder, Richard F.; Mitsuyasu, Ronald T. // Journal of Cancer Epidemiology;11/2/2016, p1 

    The objective of this study was to explore the cancer incidence rates among HIV-infected persons with commercial insurance who were on antiretroviral therapy and compare them with those rates in the general population. Paid health insurance claims for 63,221 individuals 18 years or older, with...

  • Temporal Trends in Highly Active Antiretroviral Therapy Initiation among Injection Drug Users in Baltimore, Maryland, 1996-2008. Mehta, Shruti H.; Kirk, Gregory D.; Astemborski, Jacquie; Galai, Noya; Celentano, David D. // Clinical Infectious Diseases;6/15/2010, Vol. 50 Issue 12, p1664 

    Background. We characterized temporal trends in highly active antiretroviral therapy (HAART) initiation (1996-2008) among treatment-eligible persons in a community-based cohort of current and former injection drug users (IDUs) in Baltimore, Maryland. Methods. The AIDS Linked to the IntraVenous...

  • HIV Status Disclosure and Retention in Care in HIVInfected Adolescents on Antiretroviral Therapy (ART) in West Africa. Arriv�, Elise; Dicko, Fatoumata; Amghar, Hind; Aka, Addi Edmond; Dior, H�l�ne; Bouah, Belinda; Traor�, Mariam; Ogbo, Patricia; Dago-Akribi, Hortense Aka; Eboua, Tanoh Kassi F.; Kouakou, Kouadio; Sy, Haby Signate; Alioum, Ahmadou; Dabis, Fran�ois; Ekou�vi, Didier Koumavi; Leroy, Val�riane // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Objective: We assessed the effect of HIV status disclosure on retention in care from initiation of antiretroviral therapy (ART) among HIV-infected children aged 10 years or more in Cote d'Ivoire, Mali and S�n�gal. Methods: Multi-centre cohort study within five paediatric clinics...

  • Imipramine Induced Elevation of Prolactin Levels in Patients with HIV/AIDS Improved their Immune Status. Orlander, H.; Peter, S.; Jarvis, M.; Ricketts-Hall, L. // West Indian Medical Journal;Jun2009, Vol. 58 Issue 3, p207 

    Prolactin is known to have significant immunomodulatory properties. Imipramine, a monoamine oxidase inhibitor, stimulates prolactin production because it decreases dopamine which inhibits secretion of prolactin. The study objective was to determine if use of imipramine can result in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics