TITLE

THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT

AUTHOR(S)
NUNES, Cynara Carvalho; MATTE, Maria Cristina Cotta; DIAS, Claudia Fontoura; ARAÚJO, Leonardo Augusto Luvison; GUIMARÃES, Luciano Santos Pinto; ALMEIDA, Sabrina; BRÍGIDO, Luis Fernando Macedo
PUB. DATE
May 2014
SOURCE
Revista do Instituto de Medicina Tropical de Sao Paulo;May/Jun2014, Vol. 56 Issue 3, p205
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. Methods: From July/2004 to December/2005, 135 HIV-infected patients were recruited. The partial pol region was subtyped by phylogeny. A generalized estimating equation (GEE) model was used to examine the relationship between viral subtype, CD4+ T cell count and viral load levels before antiretroviral therapy. Hazard ratio (Cox regression) was used to evaluate factors associated with viral suppression (viral load < 50 copies/mL at six months). Results: Main HIV-1 subtypes included B (29.4%), C (28.2%), and CRF31_BC (23.5%). Subtypes B and C showed a similar trend in CD4+ T cell decline. Comparison of non-B (C and CRF31_BC) and B subtypes revealed no significant difference in the proportion of patients with viral suppression at six months (week 24). Higher CD4+ T cell count and lower viral load were independently associated with viral suppression. Conclusion: No significant differences were found between subtypes; however, lower viral load and higher CD4+ T cell count before therapy were associated with better response.
ACCESSION #
96033811

 

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