Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies

Abril-Ulloa, Victoria; Flores-Mateo, Gemma; Solà-Alberich, Rosa; Manuel-y-Keenoy, Begoña; Arija, Victoria
June 2014
BMC Public Health;2014, Vol. 14 Issue 1, p517
Academic Journal
Background Elevated ferritin levels have been associated with single cardiovascular risk factors but the relationship to the presence of metabolic syndrome is inconclusive. The aim of this systematic review and meta-analysis of published observational studies was to estimate the association between serum ferritin levels and metabolic syndrome in adults. Methods The Pubmed, SCOPUS and the Cochrane Library databases were searched for epidemiological studies that assessed the association between ferritin levels and metabolic syndrome and were published before September 2013. There were no language restrictions. Two investigators independently selected eligible studies. Measures of association were pooled by using an inverse-variance weighted random-effects model. The heterogeneity among studies was examined using the I² index. Publication bias was evaluated using the funnel plot. Results Twelve cross-sectional, one case-control and two prospective studies met our inclusion criteria including data from a total of 56,053 participants. The pooled odds ratio (OR) for the metabolic syndrome comparing the highest and lowest category of ferritin levels was 1.73 (95% CI: 1.54, 1.95; I² = 75,4%). Subgroup analyses indicate that pooled OR was 1.92 (95% CI: 1.61, 2.30; I² = 78%) for studies adjusting for C-reactive protein (CRP), and 1.52 (95% CI:1. 36, 1.69; I² = 41%) for studies that did not adjust for CRP (P = 0.044). This finding was remarkably robust in the sensitivity analysis. We did not find publication bias. Conclusions The meta-analysis suggests that increased ferritin levels are independently and positively associated with the presence of the metabolic syndrome with an odds ratio higher than 1.73.


Related Articles

  • Association between alcohol and cardiovascular disease: mendelian randomisation analysis based on individual participant data. Casas, J. P. // BMJ: British Medical Journal;7/12/2014, Vol. 349 Issue 7966, pg4164 

    The article discusses research which investigated clinical association between alcohol consumption and cardiovascular disease risks. Topics explored include the evaluation of the cardiovascular health impact of alcohol intake, the identification of the genetic variant linked to low alcohol...

  • Writing Up Clinical Research: A Statistician's View. Vickers, Andrew // JGIM: Journal of General Internal Medicine;Sep2013, Vol. 28 Issue 9, p1127 

    The author discusses the ways in avoiding missteps in clinical research reporting by statisticians. He is critical of the importance of several reporting guidelines including the standards for reporting of diagnostic accuracy (STARD), strengthening the reporting of observational studies in...

  • The Risk of Metabolic Syndrome in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies. Zhang, Jianming; Fu, Lingyu; Shi, Jingpu; Chen, Xin; Li, Yongze; Ma, Bing; Zhang, Yao // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Background:Observational studies suggest an association between the incidence of rheumatoid arthritis (RA) and the prevalence of metabolic syndrome (MetS). However, the relationship between RA and MetS is controversial and research in this area is currently lacking. Objective:The aim of...

  • Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. Prochaska, Judith J.; Hilton, Joan F. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;5/12/2012, Vol. 344 Issue 7856, p13 

    The article focuses on the research presented by Judith J Prochaska and colleagues on the systematic review and meta-analysis of the risk of cardiovascular serious events related to varenicline use for tobacco cessation. It mentions that the funds related to the study has been provided by the...

  • Vitamin D Status and Parathyroid Hormone Levels in Patients with Obstructive Sleep Apnea. Barceló, Antonia; Esquinas, Cristina; Piérola, Javier; De la Peña, Mónica; Sánchez-de-la-Torre, Manuel; Montserrat, Josep María; Marín, José María; Duran, Joaquín; Arqué, Meritxell; Bauça, Josep Miquel; Barbé, Ferrán // Respiration;Oct2013, Vol. 86 Issue 4, p295 

    Background: Vitamin D insufficiency and high levels of parathyroid hormone (PTH) appear to be emerging risk factors for metabolic syndrome (MS), diabetes and cardiovascular disease, conditions that occur frequently in patients with obstructive sleep apnea syndrome (OSAS). Objectives: This study...

  • Metabolic Syndrome in People Suffering from Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis. Bartoli, Francesco; Carrà, Giuseppe; Crocamo, Cristina; Carretta, Daniele; Clerici, Massimo // Metabolic Syndrome & Related Disorders;Oct2013, Vol. 11 Issue 5, p301 

    Background: Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We...

  • Metabolic Syndrome Risk after Gestational Diabetes: A Systematic Review and Meta-Analysis. Xu, Yuhong; Shen, Shutong; Sun, Lizhou; Yang, Haiwei; Jin, Bai; Cao, Xiaohui // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Background: A number of studies have been conducted to investigate the risk of metabolic syndrome (MS) after gestational diabetes mellitus (GDM), but the results are contradictory. Accordingly, we performed a systematic review and meta-analysis to assess the association between these two...

  • Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies. Lee, Si-Huei; Chan, Rai-Chi; Chang, Shy-Shin; Tan, Yin-Ling; Chang, Kai-Hsiang; Lee, Matthew; Chang, Huai-En; Lee, Chien-Chang // Supportive Care in Cancer;Feb2014, Vol. 22 Issue 2, p553 

    Purpose: This study aims to systematically review observational studies evaluating the use of bisphosphonates (BPs) and risk of osteonecrosis of the jaw (ONJ) among cancer patients. Methods: PubMed, Embase, and Cochrane Library were screened from database inception to Aug 2012. Two reviewers...

  • Smoking and Risk of Erectile Dysfunction: Systematic Review of Observational Studies with Meta-Analysis. Cao, Shiyi; Yin, Xiaoxu; Wang, Yunxia; Zhou, Hongfeng; Song, Fujian; Lu, Zuxun // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Background: There are many recent observational studies on smoking and risk of erectile dysfunction (ED) and whether smoking increases the risk of ED is still inconclusive. The objective of this meta-analysis was to synthesize evidence from studies that evaluated the association between smoking...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics