HIV-2 viral tropism influences CD4+ T cell count regardless of viral load

Treviño, Ana; Soriano, Vicente; Poveda, Eva; Parra, Patricia; Cabezas, Teresa; Caballero, Estrella; Roc, Lourdes; Rodríguez, Carmen; Eiros, Jose M.; Lopez, Mariola; De Mendoza, Carmen
August 2014
Journal of Antimicrobial Chemotherapy (JAC);Aug2014, Vol. 69 Issue 8, p2191
Academic Journal
Background HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in comparison with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails to provide optimal CD4 recovery. Methods We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viral tropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA. Results From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3 sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%). Patients with X4 viruses had lower median CD4+ cell counts than patients with R5 viruses [130 (17–210) versus 359 (180–470) cells/mm3; P = 0.007]. This was true even considering only the subset of 19 patients on antiretroviral therapy [94 (16–147) versus 184 (43–368) cells/mm3; P = 0.041]. In multivariate analysis, significant differences in CD4+ cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender, antiretroviral therapy and viral load. Conclusions The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+ cell counts, regardless of antiretroviral treatment. Along with CD4+ cell counts, viral tropism testing may assist decisions about when to initiate antiretroviral therapy in HIV-2-infected individuals.


Related Articles

  • Relationship between HIV/Highly Active Antiretroviral Therapy (HAART)—Associated Lipodystrophy Syndrome and Stavudine-Triphosphate Intracellular Levels in Patients with Stavudine-Based Antiretroviral Regimens. Domingo, Pere; Cabeza, Maria Carmen; Pruvost, Alain; Salazar, Juliana; del Mar Gutierrez, Maria; Mateo, Maria Gracia; Domingo, Joan C.; Fernandez, Irene; Villarroya, Francesc; Muñoz, Jessica; Vidal, Francesc; Baiget, Montserrat // Clinical Infectious Diseases;4/1/2010, Vol. 50 Issue 7, p1033 

    Background. The link between human immunodeficiency virus/highly active antiretroviral therapy (HAART)- associated lipodystrophy syndrome (HALS) and the use of thymidine analogues has been well established. However, to our knowledge, no relationship has been proven between intracellular levels...

  • Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens. Hogg, Robert S.; Yip, Benita; Kully, Charlotte; Craib, Kevin J.P.; O'Shaughnessy, Michael V.; Schechter, Martin T.; Montaner, Julio S.G. // CMAJ: Canadian Medical Association Journal;3/09/99, Vol. 160 Issue 5, p659 

    Compares mortality and AIDS-free survival among HIV-infected patients in British Columbia who were treated with double- and triple-drug regimes. Methods; Results; Interpretation that treatment with a triple-drug antiretroviral regimen comprising 2 nucleoside analogue reverse transcriptase...

  • Temporal trends in presentation for outpatient HIV medical care 2000-2010: implications for short-term mortality. Seal, Paula; Jackson, David; Chamot, Eric; Willig, James; Nevin, Christa; Allison, Jeroan; Raper, James; Kempf, Mirjam; Schumacher, Joseph; Saag, Michael; Mugavero, Michael; Seal, Paula S; Jackson, David A; Willig, James H; Nevin, Christa R; Allison, Jeroan J; Raper, James L; Kempf, Mirjam C; Schumacher, Joseph E; Saag, Michael S // JGIM: Journal of General Internal Medicine;Jul2011, Vol. 26 Issue 7, p745 

    Background: Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications.Objective: To assess temporal...

  • Global Response to HIV: Treatment as Prevention, or Treatment for Treatment? Sigaloff, Kim C. E.; Lange, Joep M. A.; Montaner, Julio // Clinical Infectious Diseases;Jul2014, Vol. 59 Issue suppl_1, pS7 

    The concept of “treatment as prevention” has emerged as a means to curb the global HIV epidemic. There is, however, still ongoing debate about the evidence on when to start antiretroviral therapy in resource-poor settings. Critics have brought forward multiple arguments against a...

  • Sequential vs. simultaneous antiretroviral HIV therapy. Huffman, Grace Brooke // American Family Physician;11/15/1998, Vol. 58 Issue 8, p1845 

    Focuses on how antiretroviral therapy that consists of a combination of two nucleoside analog reverse transcriptase inhibitors can suppress viral load in patients with human immunodefiency virus (HIV) infection. Methods used in the study; Results and discussion; Conclusion.

  • Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis Suthar, Amitabh B.; Lawn, Stephen D.; del Amo, Julia; Getahun, Haileyesus; Dye, Christopher; Sculier, Delphine; Sterling, Timothy R.; Chaisson, Richard E.; Williams, Brian G.; Harries, Anthony D.; Granich, Reuben M. // PLoS Clinical Trials;Jul2012, Vol. 7 Issue 7, p1 

    In a systematic review and meta-analysis, Amitabh Suthar and colleagues investigate the association between antiretroviral therapy and the reduction in the incidence of tuberculosis in adults with HIV infection.

  • The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy. Yuncong Wang; Hui Xing; Lingjie Liao; Zhe Wang; Bin Su; Quanbi Zhao; Yi Feng; Pengfei Ma; Jia Liu; Jianjun Wu; Yuhua Ruan; Yiming Shao // AIDS Research & Therapy;2014, Vol. 11, p1 

    Objective We built a cohort study of HIV patients taking long-term first-line Antiretroviral Therapy in 2003. In this assay, we focused on the development of primary drug resistance mutations against Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), K103N, Y181C and G190A. Method The...

  • Non-physician clinician provided HIV treatment results in equivalent outcomes as physician-provided care: a meta-analysis. Emdin, Connor A; Chong, Nicholas J; Millson, Peggy E // Journal of the International AIDS Society;2013, Vol. 16 Issue 1, p1 

    Introduction: A severe healthcare worker shortage in sub-Saharan Africa is inhibiting the expansion of HIV treatment. Task shifting, the transfer of antiretroviral therapy (ART) management and initiation from doctors to nurses and other non-physician clinicians, has been proposed to address this...

  • Introduction. Murphy, Robert L. // Clinical Infectious Diseases;6/1/2000 Supplement 2, Vol. 30, pS95 

    Discusses the challenges faced by clinicians in choosing an effective treatment regimen for patients with HIV infections. Decrease in the success rate and sustained treatment response to second-line therapies in clinics; Need to find effective treatment options that have favorable...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics