TITLE

Impact of pharmacist interventions on drug-related problems and laboratory markers in outpatients with human immunodeficiency virus infection

AUTHOR(S)
Rezende, Caroline de Godoi; Molino, Costa; Carnevale, Renata Cavalcanti; Rodrigues, Aline Teotonio; Visacri, Marília Berlofa; Moriel, Patricia; Mazzola, Priscila Gava
PUB. DATE
August 2014
SOURCE
Therapeutics & Clinical Risk Management;2014, Vol. 10, p631
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Substantial complexity has been introduced into treatment regimens for patients with human immunodeficiency virus (HIV) infection. Many drug-related problems (DRPs) are detected in these patients, such as low adherence, therapeutic inefficacy, and safety issues. We evaluated the impact of pharmacist interventions on CD4+ T-lymphocyte count, HIV viral load, and DRPs in patients with HIV infection. Methods: In this 18-month prospective controlled study, 90 outpatients were selected by convenience sampling from the Hospital Dia-University of Campinas Teaching Hospital (Brazil). Forty-five patients comprised the pharmacist intervention group and 45 the control group; all patients had HIV infection with or without acquired immunodeficiency syndrome. Pharmaceutical appointments were conducted based on the Pharmacotherapy Workup method, although DRPs and pharmacist intervention classifications were modified for applicability to institutional service limitations and research requirements. Pharmacist interventions were performed immediately after detection of DRPs. The main outcome measures were DRPs, CD4+ T-lymphocyte count, and HIV viral load. Results: After pharmacist intervention, DRPs decreased from 5.2 (95% confidence interval [CI] =4.1-6.2) to 4.2 (95% CI =3.3-5.1) per patient (P=0.043). A total of 122 pharmacist interventions were proposed, with an average of 2.7 interventions per patient. All the pharmacist interventions were accepted by physicians, and among patients, the interventions were well accepted during the appointments, but compliance with the interventions was not measured. A statistically significant increase in CD4+ T-lymphocyte count in the intervention group was found (260.7 cells/mm3 [95% CI =175.8-345.6] to 312.0 cells/mm3 [95% CI =23.5-40.6], P=0.015), which was not observed in the control group. There was no statistical difference between the groups regarding HIV viral load. Conclusion: This study suggests that pharmacist interventions in patients with HIV infection can cause an increase in CD4+ T-lymphocyte counts and a decrease in DRPs, demonstrating the importance of an optimal pharmaceutical care plan.
ACCESSION #
97922913

 

Related Articles

  • Incidence of AIDS-defining illness decreased with higher CD4 counts.  // Infectious Disease News;Sep2013, Vol. 26 Issue 9, p44 

    The article focuses on the lower chances of AIDS-defining illnesses with the higher number of CD4 cell counts, which was revealed by a work by the researchers with the opportunistic infections working group of the CO-HERE study.

  • Course and Clinical Significance of CD8+ T-Cell Counts in a Large Cohort of HIV-Infected Individuals. Helleberg, Marie; Kronborg, Gitte; Ullum, Henrik; Ryder, Lars P.; Obel, Niels; Gerstoft, Jan // Journal of Infectious Diseases;6/1/2015, Vol. 211 Issue 11, p1726 

    Objectives. To examine trajectories of CD8+ T-cell counts before and after combination antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-infected individuals and associations with mortality. Methods. CD8+ T-cell counts were measured in 3882 HIV-infected individuals who received...

  • HIV Testing and Re-engagement for Individuals with Previously Diagnosed HIV Infection in New Orleans, Louisiana. Humphrey, John; Hadi, Christiane M.; Richey, Lauren E. // AIDS Patient Care & STDs;Sep2012, Vol. 26 Issue 9, p509 

    No abstract available.

  • Late presentation of HIV infection: predictors of delayed diagnosis and survival in Eastern Sicily. CELESIA, B. M.; CASTRONUOVO, D.; PINZONE, M. R.; BELLISSIMO, F.; MUGHINI, M. T.; LUPO, G.; SCARPINO, M. R.; GUSSIO, M.; PALERMO, F.; COSENTINO, S.; CACOPARDO, B.; NUNNARI, G. // European Review for Medical & Pharmacological Sciences;Aug2013, Vol. 17 Issue 16, p2218 

    OBJECTIVES: Across Europe, more than one third of patients are diagnosed with HIV infection late. Late presentation for care has been associated with higher risk of clinical progression and mortality. In the present study, we evaluated the prevalence, epidemiological characteristics and survival...

  • MACH14: A Multi-Site Collaboration on ART Adherence Among 14 Institutions. Liu, Honghu; Wilson, Ira; Goggin, Kathy; Reynolds, Nancy; Simoni, Jane; Golin, Carol; Rosen, Marc; Gross, Robert; Wagner, Glenn; Remien, Robert; Schneiderman, Neil; Erlen, Judith; Arnsten, Julia; Bangsberg, David // AIDS & Behavior;Jan2013, Vol. 17 Issue 1, p127 

    The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a...

  • Retention of antiretroviral naïve patients registered in HIV care in a program clinic in Pune, India. Ghate, Manisha V.; Zirpe, Sunil S.; Gurav, Nilam P.; Rewari, Bharat B.; Gangakhedkar, Raman R.; Paranjape, Ramesh S. // Indian Journal of Sexually Transmitted Diseases;Jul-Dec2014, Vol. 35 Issue 2, p124 

    Background: Retention in HIV care ensures delivery of services like secondary prevention, timely initiation of treatment, support, and care on a regular basis. The data on retention in pre antiretroviral therapy (ART) care in India is scanty. Materials and Methods: Antiretroviral naïve...

  • TREATMENT TIME. Madison, Evonne // Gay Community News;Aug2013, Issue 284, p37 

    The article discusses proper treatment strategies for human immunodeficiency virus (HIV), which is focused on improving CD4 cells count and reducing the levels of HIV or viral load.

  • Epidemiology of Oropharyngeal Candidiasis in Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Patients and CD4+ Counts. Berberi, Antoine; Noujeim, Ziad; Aoun, Georges // Journal of International Oral Health;2015, Vol. 7 Issue 3, p20 

    Background: The present study was directed to evaluate the forms of oropharyngeal candidiasis (OPC) and their correlation with CD4+ cell counts in human immunodeficiency virus (HIV) patients. Materials and Methods: This was a descriptive and analytical cross-sectional study carried out for a...

  • Longer HIV treatment linked to lower AIDS cancer rate but has differing effects on non-AIDS cancers.  // HIV Treatment ALERTS!;Mar2013, p38 

    The article presents a study from California-based Kaiser Permanente healthcare system researchers on the association of long HIV treatment to low rates of AIDS cancer. It mentions the factors which contribute to high AIDS cancer and non-AIDS cancer risk which involve a weak fighting system in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics