Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents

Khairullah, Ammar; Cousino Klein, Laura; Ingle, Suzanne M.; May, Margaret T.; Whetzel, Courtney A.; Susman, Elizabeth J.; Paus, Tomáš
September 2014
PLoS ONE;Sep2014, Vol. 9 Issue 9, p1
Academic Journal
Purpose: Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. Methods: We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant’s testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. Results: The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. Conclusions: The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics.


Related Articles

  • Spuriously Elevated Serum IGF-1 in Adult Individuals with Delayed Puberty: A Diagnostic Pitfall. Imran, Syed Ali; Pelkey, Michael; Clarke, David B.; Clayton, Dale; Trainer, Peter; Ezzat, Shereen // International Journal of Endocrinology;2010, p1 

    Seruminsulin-like growth factor-1 (IGF-1) is a sensitivemarker of growth hormone (GH) activity. The levels of IGF-1 vary widely, peaking during puberty and declining with advancing age. During adolescence, serum IGF-1 levels tend to correlate better with pubertal stage rather than chronological...

  • Adult height in children with short stature and idiopathic delayed puberty after different management. Zucchini, Stefano; Wasniewska, Malgorzata; Cisternino, Mariangela; Salerno, Mariacarolina; Iughetti, Lorenzo; Maghnie, Mohamad; Street, Maria Elisabeth; Caruso-Nicoletti, Manuela; Cianfarani, Stefano // European Journal of Pediatrics;Jun2008, Vol. 167 Issue 6, p677 

    By retrospectively collecting data from nine Italian centres of pediatric endocrinology, we assessed the different management and final outcome of children with short stature and idiopathic delayed puberty. Data were obtained in 77 patients (54 males, 23 females) diagnosed and followed-up in the...

  • Child Development and Parental Investment: Introduction. Francesconi, Marco; Heckman, James J. // Economic Journal;Oct2016, Vol. 126 Issue 596, pF1 

    This article introduces the EJ Feature on Child Development by reviewing the literature and placing the contributions of the articles in the Feature in the context of a vibrant literature.

  • Developmental Trajectories of Parental Mediation Across Early and Middle Childhood. Beyens, Ine; Valkenburg, Patti M; Piotrowski, Jessica Taylor // Human Communication Research;Apr2019, Vol. 45 Issue 2, p226 

    Despite a large body of literature on the opportunities of parental mediation to enhance positive and offset negative media effects, a long-term view as to the development of such mediation across childhood is lacking. The current study aimed to address this gap by presenting a developmental...

  • Effects of mothers’ education on parenting: an investigation across three generations. Duckworth, Kathryn; Sabates, Ricardo // London Review of Education;Nov2005, Vol. 3 Issue 3, p239 

    The paper investigates the relationship between mother’s education and her parenting using data from the child supplement of the 1958 National Child Development Study (NCDS). By considering data across generations, our dataset allows us to estimate the size of the bias in the relationship...

  • Agency and Appropriation of Voice – Cultural Differences in Parental Ideas about Young Children’s Talk. Aukrust, Vibeke Grøver // Human Development (0018716X);2001, Vol. 44 Issue 5, p235 

    The problem of how children develop culturally molded individuality through talk is approached through a discussion of the concept of appropriation of voice, developed within Bakhtinian dialogical theory. The concept turns attention to otherness and ownness as processes that are simultaneously...

  • Evaluating the Strange Situation Procedure (SSP) to Assess the Bond between Dogs and Humans. Rehn, Therese; McGowan, Ragen T. S.; Keeling, Linda J. // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    The Strange Situation Procedure (SSP) is increasingly being used to study attachment between dogs and humans. It has been developed from the Ainsworth Strange Situation Procedure, which is used extensively to investigate attachment between children and their parents. In this experiment, 12...

  • The genetic epidemiology of parental discipline. TRACEY D. WADE // Psychological Medicine;Nov2000, Vol. 30 Issue 6, p1303 

    No abstract available.

  • Sleuthing Out Precocious Puberty.  // Pediatrics for Parents;2007, Vol. 23 Issue 1, p7 

    The article presents the case of two American siblings, a 3-year-old girl and her 5-year-old brother, who suffered precocious puberty. An investigation on the case revealed that the kids' father had purchased a concentrated testosterone skin cream for cosmetic and sexual performance purposes....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics