TITLE

High Prevalence of Signs of Renal Damage Despite Normal Renal Function in a Cohort of HIV-Infected Patients: Evaluation of Associated Factors

AUTHOR(S)
Bonjoch, Anna; Juega, Javier; Puig, Jordi; Pérez-Alvarez, Nuria; Aiestarán, Aintzane; Echeverría, Patricia; Pérez, Vanessa; Clotet, Bonaventura; Romero, Ramon; Bonet, Josep; Negredo, Eugenia
PUB. DATE
October 2014
SOURCE
AIDS Patient Care & STDs;Oct2014, Vol. 28 Issue 10, p524
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Renal disorders are an emerging problem in HIV-infected patients. We performed a cross-sectional study of the first 1000 HIV-infected patients attended at our HIV unit who agreed to participate. We determined the frequency of renal alterations and its related risk factors. Summary statistics and logistic regression were applied. The study sample comprised 970 patients with complete data. Most were white (94%) and men (76%). Median (IQR) age was 48 (42-53) years. Hypertension was diagnosed in 19%, dyslipidemia in 27%, and diabetes mellitus in 3%. According to the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation, 29 patients (3%) had an eGFR<60 ml/min/1.73 m2; 18 of them (62%) presented altered albumin/creatinine and protein/creatinine (UPC or UAC) ratios. Of the patients with eGFR>60 mL/min, it was present in 293 (30%), 38 of whom (7.1%) had UPC>300 mg/g. Increased risk of renal abnormalities was correlated with hypertension (OR, 1.821 [95%CI, 1.292;2.564]; p=0.001), age (OR, 1.015 [95%CI, 1.001;1.030], per one year; p=0.040), and use of tenofovir disoproxil fumarate (TDF) plus protease inhibitor (PI), (OR, 1.401 [95%CI, 1.078;1.821]; p=0.012). Current CD4 cell count was a protective factor (OR, 0.9995 [95%CI, 0.9991;0.9999], per one cell; p=0.035). A considerable proportion of patients presented altered UPC or UAC ratios, despite having an eGFR>60 mL/min. CD4 cell count was a protective factor; age, hypertension, and use of TDF plus PIs were risk factors for renal abnormalities. Based on our results, screen of renal abnormalities should be considered in all HIV-infected patients to detect these alterations early.
ACCESSION #
98644445

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics