TITLE

PREVALENCE OF THYROID DYSFUNCTIONS AND DYSLIPIDEMIA AMONG PATIENTS WITH HIV INFECTION: A HOSPITAL BASED STUDY FROM EASTERN INDIA

AUTHOR(S)
Modak, Dolonchampa; Guha, Subhasish Kamal; Saha, Bibhuti; Mukhopadhyay, Sumi
PUB. DATE
October 2014
SOURCE
International Journal of Pharmacy;2014, Vol. 4 Issue 4, p226
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to estimate the prevalence of thyroid dysfunctions and dyslipidemia among patients living with HIV and to investigate the associated factors. This cross sectional comparative group study was conducted between Feb 2013 to Jan 2014 at a single centre. The enrolled subjects were grouped in three categories, Group A (n= 42) comprising of ART naïve HIV patients at baseline, Group B (n= 48) comprising of HIV patients starting ART at baseline, Group C (n= 19) comprising of HIV patients at baseline and after 6 months follow-up. Study population included 109 (59 males, 50 females) HIV patients with a mean age of 35.59 ± 10.2 years. Taken together, in Group A and B, 20% had hypothyroidism. Further, 1 patient each from both the groups had hyperthyroidism. In the present study, 12 % of HIV patients with CD4<200 Cells/mm3 had thyroid dysfunctions whereas 2% with CD4 200-350 Cells/mm3 and 7 % patients with CD4>350 Cells/mm3 had abnormal thyroid profile. In the follow up Group C, 2 patients developed Thyroid dysfunctions after 6 months on ART. Additionally, hypertriglyceridemia was found prevalent among HIV subjects with hypothyroidism in all the groups. Current National AIDS Control organization (NACO), India guidelines doesn't recommend mandatory monitoring of thyroid function tests (TFT) in asymptomatic HIV patients. Considering the prevalence of Thyroid dysfunctions among HIV patients, TFT along with other blood investigations is suggested. However, larger population based study is required for proper validation.
ACCESSION #
98797081

 

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