TITLE

Possibility of scrub typhus in fever of unknown origin (FUO) cases: An experience from Rajasthan

AUTHOR(S)
Bithu, R.; Kanodia, V.; Maheshwari, R. K.
PUB. DATE
October 2014
SOURCE
Indian Journal of Medical Microbiology;Oct-Dec214, Vol. 32 Issue 4, p387
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Fever of unknown origin (FUO) has multiple causes. Scrub typhus is less known cause of FUO in India. The present study reports a recent epidemic of scrub typhus amongst cases of FUO from different areas of Rajasthan, India. There was high mortality in undiagnosed cases of FUO which lead to the diagnosis of scrub typhus. Objective: To study the possibility of scrub typhus as a causative factor in FUO cases by qualitative detection of IgM antibodies with ELISA. Materials and Methods: From September 2012 to December 2012, 271 serum samples of FUO cases were analysed for IgM antibodies to Orientia tsutsugamushi along with dengue, malaria, typhoid, tuberculosis and brucellosis. Results: Scrub typhus IgM antibodies by ELISA were detected in 133 (49.1%) patients. Scrub typhus positivity was significantly higher among female in comparison to males (P < 0.05). Maximum positivity of scrub typhus was found in females of 46-60 years age group. The laboratory parameters were abnormal in most of the patients as evident by thrombocytopenia (63%), deranged liver functions (56%) and renal functions (25%). Conclusion: The present study emphasises the importance of scrub typhus among cases of FUO especially after rainy season and during early cooler months. The study also highlights the significance of ELISA method for rapid and early reporting and ruling out scrub typhus in FUO cases.
ACCESSION #
98887327

 

Related Articles

  • Serodiagnosis of Scrub Typhus Infection: Comparison of IgM Enzyme Linked Immuno Sorbent Assay (ELISA) and Weil-Felix Test. VIGNESHWARI, M.; PURTY, SHASHIKALA; SUJATHA // Australasian Medical Journal;Apr2013, Vol. 6 Issue 4, p256 

    Introduction Scrub typhus, an acute infectious disease caused by Orientia tsutsugamushi, is endemic to India. A recent report suggests that there is resurgence of this disease in some parts of India. The diagnosis and surveillance of this disease is challenging due to its non-specific clinical...

  • Brucellosis and the Respiratory System. Pappas, Georgios; Bosilkovski, Mile; Akritidis, Nikolaos; Mastora, Maria; Krteva, Liliana; Tsianos, Epaminondas // Clinical Infectious Diseases;10/1/2003, Vol. 37 Issue 7, p95 

    Describes the involvement of the respiratory system in brucellosis in Balkan Peninsula. Accounts on the predominance of monocytic or lymphocytic infiltrates; Inhalation of the infectious aerosols particles; Use of enzyme-linked immunosorbent assay to detect immunoglobulin M antibodies.

  • Multiple Eschars in Scrub Typhus. Kaushik, Rajeev Mohan; Kaushik, Reshma; Bhargava, Anurag // Tropical Medicine & Health;2014, Vol. 42 Issue 2, p65 

    An eschar is highly suggestive of scrub typhus in a case of fever. Multiple eschars are rare in scrub typhus. We present a picture of multiple eschars in scrub typhus

  • Outbreak of scrub typhus in the North East Himalayan region-Sikkim: An emerging threat. Gurung, S.; Pradhan, J.; Bhutia, P. Y. // Indian Journal of Medical Microbiology;Jan-Mar2013, Vol. 31 Issue 1, p72 

    Scrub typhus is an acute febrile illness that is known to be endemic in the South East Asian countries and the Western Pacific region. We here report an outbreak in the tiny Himalayan state of Sikkim. Patients with pyrexia of unknown origin were evaluated. They were screened by Weil-Felix test...

  • Outbreak of scrub typhus in Puducherry & Tamil Nadu during cooler months. Stephen, Selvaraj; Sangeetha, Balakrishnan; Ambroise, Stanley; Sarangapani, Kengamuthu; Gunasekaran, Dhandapany; Hanifah, Mohamed; Somasundaram, Subramanian // Indian Journal of Medical Research;Nov2015, Vol. 142 Issue 5, p591 

    Background & objectives: The southern part of India has witnessed an increase in scrub typhus (ST) during the past ten years. ST outbreaks occurred during winter months but at intervals of one to three years. With only a few reports of ST in Puducherry, this study was undertaken to look for the...

  • Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone. Schoepp, Randal J.; Rossi, Cynthia A.; Khan, Sheik H.; Goba, Augustine; Fair, Joseph N. // Emerging Infectious Diseases;Jul2014, Vol. 20 Issue 7, p1176 

    Sierra Leone in West Africa is in a Lassa fever-hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of ≈500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only...

  • Tsutsugamushi Disease (Scrub Typhus) Meningoencephalitis in North Eastern India: A Prospective Study. Sharma, S. R.; Masaraf, H.; Lynrah, K. G.; Lyngdoh, M. // Annals of Medical & Health Sciences Research;May2015, Vol. 5 Issue 3, p163 

    Background: Scrub typhus is rampant in northern, eastern, and southern India. Central nervous system involvement in the form of meningitis or meningoencephalitis is common in scrub typhus. As specific laboratory methods remain inadequate or inaccessible in developing countries, prompt diagnosis...

  • Detection, Isolation and Confirmation of Crimean-Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010-2011. Mourya, Devendra T.; Yadav, Pragya D.; Shete, Anita M.; Gurav, Yogesh K.; Raut, Chandrashekhar G.; Jadi, Ramesh S.; Pawar, Shailesh D.; Nichol, Stuart T.; Mishra, Akhilesh C. // PLoS Neglected Tropical Diseases;May2012, Vol. 6 Issue 5, p1 

    Background: In January 2011, human cases with hemorrhagic manifestations in the hospital staff were reported from a tertiary care hospital in Ahmadabad, India. This paper reports a detailed epidemiological investigation of nosocomial outbreak from the affected area of Ahmadabad, Gujarat, India....

  • Comparison of ELISA and indirect immunofluorescent antibody assay detecting Coxiella burnetii IgM phase II for the diagnosis of acute Q fever. Meekelenkamp, J.; Schneeberger, P.; Wever, P.; Leenders, A. // European Journal of Clinical Microbiology & Infectious Diseases;Jun2012, Vol. 31 Issue 6, p1267 

    A commercially available enzyme-linked immunosorbent assay (ELISA) detecting Coxiella burnetii phase II-specific IgM for the diagnosis of acute Q fever was compared with indirect immunofluorescent antibody assay (IFA). IFA is the current reference method for the detection of antibodies against...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics