January 2010
Reactions Weekly;1/23/2010, Issue 1285, p13
Case Study
The article describes the cases of two 24-year-old male patients who developed severe and prolonged cholestasis while receiving cotrimoxazole for treatment of Pneumocystis carinii pneumonia (PCP). The first patient developed respiratory failure and required ventilation after receiving cotrimoxazole and prednisolone intravenously. The second patient was hospitalized for respiratory decline, which progressed under mechanical ventilation, after treatment with intravenous (IV) cotrimoxazole.


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