Cardiac hypertrophy and oxidative stress: a leap of faith or stark reality?

Lang, D.
April 2002
Heart;Apr2002, Vol. 87 Issue 4, p316
Academic Journal
This article focuses on a study related to the cardiac hypertrophy and oxidative stress. The term "oxidative stress" has become something of a buzz phrase in recent years, being implicated in countless disease processes. Given that cardiac myocyte mitochondria can generate reactive oxygen species during heart failure, treatment with an antioxidant could provide significant benefit in preventing the transition from compensatory hypertrophy to cardiomyopathy and failure often seen in FRDA. It has been suggested that decreased or absent frataxin impairs early antioxidant defenses in FRDA.


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