HIV clinical trials are not enough

Millson, Margaret E.; Rachlis, Anita R.
March 1999
CMAJ: Canadian Medical Association Journal;3/09/99, Vol. 160 Issue 5, p669
Academic Journal
Editorial. Discusses antiretroviral drug regimens for HIV infection. The paradigm of HIV therapy being complete suppression of viral replication to preserve and restore immune function and to delay or prevent the emergence of drug resistance; Reference to a study by Robert S. Hogg and associates, which used the HIV/AIDS Drug Treatment Program in British Columbia as a database, in this issue.


Related Articles

  • Management of the Adverse Effects of Antiretroviral Therapy and Medication Adherence. Max, Blake; Sherer, Renslow // Clinical Infectious Diseases;6/1/2000 Supplement 2, Vol. 30, pS96 

    Examines the therapeutic agents included in the highly active antiretroviral therapy (HAART) for the treatment of patients with HIV infections. Link between poor adherence and failure of antiretroviral therapy; Threat of short term-adverse effects to successful introduction and maintenance of...

  • Introduction. Murphy, Robert L. // Clinical Infectious Diseases;6/1/2000 Supplement 2, Vol. 30, pS95 

    Discusses the challenges faced by clinicians in choosing an effective treatment regimen for patients with HIV infections. Decrease in the success rate and sustained treatment response to second-line therapies in clinics; Need to find effective treatment options that have favorable...

  • An HIV-Positive Patient Who Avoids Treatment. Legg, Jill J.; Goldschmidt, Ronald H. // American Family Physician;6/1/1999, Vol. 59 Issue 11, p3252 

    Comments on the case of an HIV-positive patient who avoids treatment. Reason for HIV-positive patients to avoid health care; Suggestions on how physicians can help HIV-positive patients go for treatment.

  • Relationship between HIV/Highly Active Antiretroviral Therapy (HAART)—Associated Lipodystrophy Syndrome and Stavudine-Triphosphate Intracellular Levels in Patients with Stavudine-Based Antiretroviral Regimens. Domingo, Pere; Cabeza, Maria Carmen; Pruvost, Alain; Salazar, Juliana; del Mar Gutierrez, Maria; Mateo, Maria Gracia; Domingo, Joan C.; Fernandez, Irene; Villarroya, Francesc; Muñoz, Jessica; Vidal, Francesc; Baiget, Montserrat // Clinical Infectious Diseases;4/1/2010, Vol. 50 Issue 7, p1033 

    Background. The link between human immunodeficiency virus/highly active antiretroviral therapy (HAART)- associated lipodystrophy syndrome (HALS) and the use of thymidine analogues has been well established. However, to our knowledge, no relationship has been proven between intracellular levels...

  • Test predicts if aggressive therapy will help patients with advanced HIV. Rose, Verna L.; Zolopa, Andrew // American Family Physician;11/15/1998, Vol. 58 Issue 8, p1831 

    Presents information on a study which shows that an antiviral resistance test can predict which patients with HIV infection may benefit from aggressive follow-up treatment after combination therapy has failed. Materials and methods used in the study: Results and discussion; Conclusion.

  • Adolescents and HIV in Sub-Saharan Africa: A Timely Issue and Missed Opportunity. Coovadia, Hoosen; Mantell, Joanne E. // Clinical Infectious Diseases;10/1/2010, Vol. 51 Issue 7, p852 

    The authors comment on issue related to the management of adult patients in Sub-Saharan, Africa who were infected with human immunodeficiency virus (HIV). They cite the context of the article by Ferrand and colleagues which focuses on the undiagnosed cases of HIV among adults living in the...

  • Activity of the Combination of Nelfinavir and Saquinavir Against Human Immunodeficiency Virus After Failure of Prior Protease Inhibitor Therapy. Kravcik, Stephen; Victor, Gary; Angel, Jonathan B.; Badley, Andrew D.; Cameron, D. William // Clinical Infectious Diseases;9/1/1999, Vol. 29 Issue 3, p702 

    Reports on the effectiveness of combining nelfinavir and saquinavir for the treatment of HIV infections. Details of a retrospective study on HIV-positive patients prescribed with nelfinavir and saquinavir; Effects of the drugs on the viral levels of the patients; Importance of treatment changes...

  • Determinants of Antimicrobial Prophylaxis Use and Treatment for Wasting among Patients with Advanced Human Immunodeficiency Virus Disease in the United States, 1995-1998. Murphy, Edward L.; Assmann, Susan F.; Collier, Ann C.; Flanigan, Timothy P.; Kumar, Princy N.; Wallach, Fran R.; Krubel, Sharon // Clinical Infectious Diseases;1/1/2001, Vol. 32 Issue 1, p116 

    Discusses a study which measured the prevalence of antimicrobial prophylaxis use and treatment for HIV wasting among patients with advanced HIV. Characteristics of the patients; Data and methodology; Prophylaxis for pneumocystis carinii pneumonia and mycobacterium avium complex.

  • Primary care for patients infected with human immunodeficiency virus: a randomized controlled trial. Keitz, Sheri A.; Box, Tamara L.; Homan, Rick K.; Bartlett, John A.; Oddone, Eugene Z.; Keitz, S A; Box, T L; Homan, R K; Bartlett, J A; Oddone, E Z // JGIM: Journal of General Internal Medicine;Sep2001, Vol. 16 Issue 9, p573 

    Objective: To measure the impact of a teaching intervention and to compare process and outcomes of care for HIV-infected patients randomly assigned to a general medicine clinic (GMC) or an infectious disease clinic (IDC) for primary care.Design: Prospective, randomized,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics