Keeping sight of the goal

July 2006
Nature Reviews Drug Discovery;Jul2006, Vol. 5 Issue 7, p525
Academic Journal
The call by the World Health Organization for all clinical trials to be registered, and for information to be fully disclosed at the time of registration, has antagonized the pharmaceutical industry. More pragmatism could be needed if the important initiative to improve the transparency of clinical research is to maintain momentum.


Related Articles

  • Industry anger over stringent trial disclosure requirements. Wadman, Meredith // Nature Reviews Drug Discovery;Jul2006, Vol. 5 Issue 7, p527 

    The article focuses on the argument over the World Health Organization's (WHO) request to register early stage trials. In an attempt to harmonize the process, the WHO has published universal standards for revealing data of clinical trials. The new standards endorse registration of all trials...

  • Clinical trials initiative: patients or patents? Humphreys, Gary // Bulletin of the World Health Organization;Jul2006, Vol. 84 Issue 7, p513 

    The article reports on the concerns of the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) regarding the new rules proposed by the World Health Organization (WHO) on the disclosure of data when researchers register their planned clinical trials. The IFPMA has...

  • Engaging Tomorrow's Volunteers Through Museum Learning. Getz, Kenneth A. // Applied Clinical Trials;Jun/Jul2014, Vol. 23 Issue 6/7, p18 

    The article discusses the efforts to provide outreach and education to inform patients and the public about the clinical research process. The author reveals that the National and international polls conducted by the Center for Information and Study on Clinical Research Participation (CISCRP)...

  • Reporting of Methodologic Information on Trial Registries for Quality Assessment: A Study of Trial Records Retrieved from the WHO Search Portal. Reveiz, Ludovic; Chan, An-Wen; Krleža-Jericć, Karmela; Granados, Carlos Eduardo; Pinart, Mariona; Etxeandia, Itziar; Rada, Diego; Martinez, Monserrat; Bonfill, Xavier; Cardona, Andrés Felipe // PLoS Clinical Trials;Aug2010, Vol. 7 Issue 8, Special section p1 

    Background: Although randomized clinical trials (RCTs) are considered the gold standard of evidence, their reporting is often suboptimal. Trial registries have the potential to contribute important methodologic information for critical appraisal of study results. Methods and Findings: The...

  • Clinical Trial Registration. Laine, Christine; Horton, Richard; DeAngelis, Catherine D.; Drazen, Jeffrey M.; Frizelle, Frank A.; Godlee, Fiona; Haug, Charlotte; Hébert, Paul C.; Kotzin, Sheldon; Marusic, Ana; Sahni, Peush; Schroeder, Torben V.; Sox, Harold C.; Van Der Weyden, Martin B.; Verheugt, Freek W.A. // JAMA: Journal of the American Medical Association;7/4/2007, Vol. 298 Issue 1, p93 

    The authors reflect on the state of clinical trial registration. In 2005, the International Committee of Medical Journal Editors (ICMJE) initiated a policy which required medical investigators to disclose date related to clinical trial designs to a clinical trials registry prior to the...

  • Legislation for trial registration and data transparency. Zhao-Xiang Bian; Tai-Xiang Wu // Trials;2010, Vol. 11, p64 

    Public confidence in clinical trials has been eroded by data suppression, misrepresentation and manipulation. Although various attempts have been made to achieve universal trial registration- e.g., Declaration of Helsinki, WHO clinical Trial Registry Platform (WHO ICTRP), the International...

  • An international standard for disclosure of clinical trial information. Godlee, Fiona // BMJ: British Medical Journal (International Edition);5/13/2006, Vol. 332 Issue 7550, p1107 

    The article comments on the efforts to create a comprehensive registration for clinical trials. Current discussions center on negotiations with the pharmaceutical and medical devices industries about the information to be registered for which trials and when it should be done. An international ...

  • Evidence for global health. Jha, Prabhat; Lavery, James V. // CMAJ: Canadian Medical Association Journal;5/25/2004, Vol. 170 Issue 11, p1687 

    Discusses research being done on the paucity of randomized controlled trials (RCT) in addressing major global diseases. Reference to a study by P.A. Rochon et al., published in the May 25, 2004 issue of the "Canadian Medical Association Journal"; Lack of evidence from RCT being directed to...

  • WHO clinical trails initiative to protect the public.  // Bulletin of the World Health Organization;Jan2006, Vol. 84 Issue 1, p10 

    The article reports that World Health Organization (WHO) is developing a common set of rules for registering clinical trials. The WHO International Clinical Trials Registry Platform is a major initiative to bring clinical registers together in a global network to offer a single point of access...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics