Novel antibody switching defects in human patients

Manis, John P.; Alt, Frederick W.
July 2003
Journal of Clinical Investigation;7/1/2003, Vol. 112 Issue 1, p19
Academic Journal
journal article
Comments on a study which characterized hyper-immunoglobulin M syndrome (HIGM) type 4, a defect in antibody gene diversification caused by a selective block in class-switch recombination (CSR). Background to HIGM; Difference between CSR and somatic hypermutation defects; Factors involved in differential processing and repair.


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