TITLE

Effects of Botulinum Toxin Landmark-Guided Intra-articular Injection in Subjects With Knee Osteoarthritis

AUTHOR(S)
Hsieh, Lin-Fen; Wu, Chia-Wei; Chou, Ching-Chieh; Yang, Sai-Wei; Wu, Shih-Hui; Lin, Yi-Jia; Hsu, Wei-Chun
PUB. DATE
December 2016
SOURCE
PM & R: Journal of Injury, Function & Rehabilitation;Dec2016, Vol. 8 Issue 12, p1127
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Increasing evidence has suggested that botulinum toxin A (BoNT/A) can inhibit the release of selected neuropeptide transmitters from primary sensory neurons. Thus, intra-articular (IA) injection therapies with BoNT/A may reduce pain in patients with knee osteoarthritis (OA).Objective: To investigate the effects of landmark-guided IA injection of BoNT/A on patients with knee OA.Design: A prospective randomized controlled trial.Setting: A rehabilitation clinic of a private teaching hospital.Patients: A total of 46 patients with symptomatic knee OA (mostly Kellgren-Lawrence grade 2-3).Methods: The patients were randomly assigned to 1 of the following groups: BoNT/A group (BoNT/A injection; n = 21) or control group (education only; n = 20). The patients in the BoNT/A group received an IA injection of 100 units of BoNT/A into the affected knee.Main Outcome Measures: The short-term (1 week posttreatment) and long-term (6 months posttreatment) effects were evaluated using a pain visual analogue scale (VAS) and questionnaires concerning functional status, including the Lequesne and Western Ontario and McMaster Universities (WOMAC) indexes.Results: The between-group comparison revealed significant differences with regard to the pain VAS score at 1 week (P < .001) and at 6 months (P = .001) posttreatment. Similar findings for the between-group comparison were observed for the WOMAC and Lequesne indexes at 6 months (P < .05) posttreatment. The pain VAS score in the BoNT/A group significantly decreased from 5.05 ± 1.12 (pretreatment) to 2.89 ± 1.04 at 1 week (P < .001) and 3.45 ± 1.70 at 6 months posttreatment (P < .001) but not in the control group (P = .476).Conclusions: The IA injection of BoNT/A provided pain relief and improved functional abilities in patients with knee OA in both the short- and long-term follow-up.Level Of Evidence: I.
ACCESSION #
120276439

 

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