Effectiveness of a Community-Based Weight Management Program for Patients Taking Antidepressants and/or Antipsychotics

Wharton, Sean; Kuk, Jennifer L.; Petrova, Lana; Rye, Peter I.; Taylor, Valerie H.; Christensen, Rebecca A.G.
September 2019
Obesity (19307381);Sep2019, Vol. 27 Issue 9, p1539
Academic Journal
journal article
Objective: This study aimed to compare weight loss (WL) outcomes for patients taking antidepressants and/or antipsychotics with those not taking psychiatric medication.Methods: A total of 17,519 adults enrolled in a lifestyle WL intervention at the Wharton Medical Clinics in Ontario, Canada, were analyzed. Sex-stratified multivariable linear regression analysis was used to examine the association of taking antidepressants, antipsychotics, both, or neither with WL when adjusting for age, initial weight, and treatment time.Results: Twenty-three percent of patients were taking at least one psychiatric medication. Patients lost a significant amount of weight (P < 0.0001) regardless of psychiatric medication use. Women taking psychiatric medications lost a similar amount of weight as women who were not (P > 0.05). Conversely, men taking antidepressants lost only slightly less weight than men taking both classes or neither class of psychiatric medication (3.2 ± 0.3 kg vs. 5.6 ± 0.9 kg and 4.3 ± 0.1 kg; P < 0.05). However, taking psychiatric medications that cause weight gain was associated with similar significant decreases in weight as taking medications that are weight neutral or associated with WL for both sexes (P > 0.05).Conclusions: Results of this study suggest that those who participate in a weight management program can lose significant amounts of weight regardless of psychiatric medication use.


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