Reported Outcomes in Perinatal Iron Deficiency Anemia Trials: A Systematic Review

Malinowski, Ann Kinga; D'Souza, Rohan; Khan, Khalid S.; Shehata, Nadine; Malinowski, Marcin; Daru, Jahnavi; Malinowski, Ann Kinga; Khan, Khalid S
September 2019
Gynecologic & Obstetric Investigation;Sep2019, Vol. 84 Issue 5, p417
Academic Journal
journal article
Background/aims: Iron deficiency (ID) and iron deficiency anemia (IDA) are global health concerns associated with adverse perinatal effects. Despite efforts taken at the international level, there is no consensus on unified prevention/treatment strategies, largely stemming from inconsistencies of outcome reporting. Our objective was to comprehensively assess outcome reporting perinatal iron intervention trials as Phase 1 of core outcome set (COS) development to inform future research.Methods: Systematic search in MEDLINE, EMBASE, Cochrane Databases, and CINAHL (January 2000 - April 2016), with inclusion of trials involving pregnant or postpartum women with ID/IDA confirmed before recruitment. Articles were independently screened and selected by 2 reviewers; data were extracted in duplicate. Quality was assessed using published scoring systems. Outcome definitions and measurement methods were tabulated.Results: Of 7,046 citations, 33 randomized controlled trials were included. Sixty-nine reported outcomes were categorized into 8 domains. High methodological quality characterized 25 (76%) studies. Reporting quality was low in 16 (49%), moderate in 13 (39%), and high in 4 (12%) studies. Variation was greatest for outcome definition, timing of assessment and measurement methods.Conclusion: This review identifies a comprehensive long-list of outcomes reported of perinatal iron interventions for ID/IDA. Beyond highlighting existing variation in outcome reporting, it provides a foundation for development of a COS for future trials.


Related Articles

  • Correction of iron deficiency anemia in pregnancy and its effects on Superoxide dismutase. Khalid, Shamaila; Ahmad, Syed Iqbal // Pakistan Journal of Pharmaceutical Sciences;Apr2012, Vol. 25 Issue 2, p423 

    Iron deficiency anemia (IDA) affects not only the hematological parameters but also disturb the oxidative balance of body. In pregnancy, this is much more considerable as oxidative stress is considered to be one of the physiological changes during this period. This study aims to observe the...

  • Clinical digest. PREGNANT WOMEN BENEFIT FROM TAKING IRON INTERMITTENTLY.  // Nursing Standard;8/15/2012, Vol. 26 Issue 50, p14 

    The article discusses research which was reported in the article "Intermittent Oral Iron Supplementation During Pregnancy" by J. Pena-Rosas et al. and found that pregnant women benefit from taking iron once or twice a week.

  • What is appropriate management of iron deficiency for young children? Bhargava, Sital; Meurer, Linda N.; Jamieson, Barbara // Journal of Family Practice;Jul2006, Vol. 55 Issue 7, p629 

    The article provides information regarding the appropriate management of iron deficiency for young children. Young children with suspected iron deficiency anemia should start treatment with oral ferrous sulfate. An increase in hemoglobin after 4 weeks supports the diagnosis of iron deficiency,...

  • Iron supplements. Smith, Haley // South African Pharmacist's Assistant;Winter2013, Vol. 13 Issue 2, p38 

    The article offers information related to iron deficiency, which can be addressed using iron supplements when the diet alone could not support the needed iron level within a time frame. It says that iron deficiency is caused by excessive loss of blood, inadequate iron absorption, and low intake...

  • Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial. Coutinho, Geraldo G. P. L.; Cury, Patrícia M.; Cordeiro, José A. // BMC Public Health;2013, Vol. 13 Issue 1, p1 

    Background: Iron-deficiency anemia is the most common type of nutritional disorder. New strategies for the treatment of anemia are very important for its reduction. The aim of this study was to assess the efficacy and feasibility of cyclical iron supplementation as a strategy to reduce the...

  • Effects of Different Doses and Duration of Iron Supplementation on Curing Iron Deficiency Anemia: an Experimental Study. Ma, Juan; Wen, Xiaosha; Mo, Fengfeng; Wang, Xiaoli; Shen, Zhilei; Li, Min // Biological Trace Element Research;Dec2014, Vol. 162 Issue 1-3, p242 

    Many controversies persist with respect to the dosage and therapeutic duration concerning iron deficiency anemia (IDA) treatment. To identify the most suitable cure, this study evaluated the effect of iron supplementation with different doses and for different time periods in rats with iron...

  • Iron Dextran Injection.  // AHFS Consumer Medication Information;Jun2020, p1 

    Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in people who cannot be treated with iron supplements taken by mouth. Iron dextran injection is in a class of medications called iron replacement products. It...

  • Identification, Prevention and Treatment of Iron Deficiency during the First 1000 Days. Burke, Rachel M.; Leon, Juan S.; Suchdev, Parminder S. // Nutrients;Oct2014, Vol. 6 Issue 10, p4093 

    Iron deficiency is a global problem across the life course, but infants and their mothers are especially vulnerable to both the development and the consequences of iron deficiency. Maternal iron deficiency during pregnancy can predispose offspring to the development of iron deficiency during...

  • Diagnostic accuracy of hemoglobin for iron deficiency in pregnancy: disclosing results of a cited clinical trial. Bresani Salvi, Cristiane C.; Braga, Maria Cynthia; Batista Filho, Malaquias // Pan American Journal of Public Health;2014, Vol. 36 Issue 2, p110 

    Objective. To analyze the accuracy of hemoglobin (Hb) concentrations as a diagnostic indicator of iron deficiency in pregnant women and to measure the efficacy of oral iron therapy using Hb z-scores rather than Hb absolute values. Methods. The sensitivity and specificity of Hb < 11.0 g/dL, and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics