Pharmacological manipulation of Bcl-2 family members to control cell death

Letai, Anthony
October 2005
Journal of Clinical Investigation;Oct2005, Vol. 115 Issue 10, p2648
Academic Journal
journal article
The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.


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