Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL

Groffen, J.; De Jong, R.; Haataja, L.; Kaartinen, V.; Heisterkamp, N.
April 1999
Leukemia (08876924);Apr1999 Supplement 1, Vol. 13, pS81
Academic Journal
journal article
The article presents information related to a study which demonstrates that tyrosine-phosphorylated proteins which specifically bind to the Crkl SH2 domain in the leukemic tissues of P190 BCR/ABL transgenic mice are identical to Hef1 /Cas-L. According to the study, Hef1 /Cas-L is similar to p130 Cas, except that the expression of Hef1 is limited to specific cell types within the hematopoietic lineage.


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