TITLE

Nipping at cardiac remodeling

AUTHOR(S)
Whelan, Russell S.; Mani, Kartik; Kitsis, Richard N.
PUB. DATE
October 2007
SOURCE
Journal of Clinical Investigation;Oct2007, Vol. 117 Issue 10, p2751
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size.
ACCESSION #
26937721

 

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