Nipping at cardiac remodeling

Whelan, Russell S.; Mani, Kartik; Kitsis, Richard N.
October 2007
Journal of Clinical Investigation;Oct2007, Vol. 117 Issue 10, p2751
Academic Journal
journal article
Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size.


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