TITLE

Association studies for asthma and atopic diseases: a comprehensive review of the literature

AUTHOR(S)

Hoffjan, Sabine; Nicolae, Dan; Ober, Carole

PUB. DATE

January 2003

SOURCE

Respiratory Research;2003, Vol. 4, p14

SOURCE TYPE

Academic Journal

DOC. TYPE

journal article

ABSTRACT

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

ACCESSION #

30729707

 

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