Association studies for asthma and atopic diseases: a comprehensive review of the literature

Hoffjan, Sabine; Nicolae, Dan; Ober, Carole
January 2003
Respiratory Research;2003, Vol. 4, p14
Academic Journal
journal article
Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.


Related Articles

  • Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial. Lascarrou, Jean Baptiste; Boisrame-Helms, Julie; Bailly, Arthur; Thuaut, Aurelie Le; Kamel, Toufik; Mercier, Emmanuelle; Ricard, Jean-Damien; Lemiale, Virginie; Colin, Gwenhael; Mira, Jean Paul; Meziani, Ferhat; Messika, Jonathan; Dequin, Pierre Francois; Boulain, Thierry; Azoulay, Elie; Champigneulle, Benoit; Reignier, Jean; Le Thuaut, Aurelie; Clinical Research in Intensive Care and Sepsis (CRICS) Group // JAMA: Journal of the American Medical Association;2/7/2017, Vol. 317 Issue 5, p483 

    Importance: In the intensive care unit (ICU), orotracheal intubation can be associated with increased risk of complications because the patient may be acutely unstable, requiring prompt intervention, often by a practitioner with nonexpert skills. Video laryngoscopy may decrease this...

  • Statistical power to detect genetic and environmental influences in the presence of data missing at random. Derks, Eske M.; Dolan, Conor V.; Boomsma, Dorret I. // Twin Research & Human Genetics;Feb2007, Vol. 10 Issue 1, p159 

    We study the situation in which a cheap measure (X) is observed in a large, representative twin sample, and a more expensive measure (Y) is observed in a selected subsample. The aim of this study is to investigate the optimal selection design in terms of the statistical power to detect genetic...

  • Commentary on: A study of genotypes, mutants, and nucleotide sequence of hepatitis B virus in Pakistan. Pourkarim, M. R.; Van Ranst, M.; Mumtaz, K. // Hepatitis Monthly;Apr2011, Vol. 11 Issue 4, p292 

    No abstract available.

  • Heritability of cortisol regulation in children. Gustafsson, Per A.; Gustafsson, Per E.; Anckarsäter, Henrik; Lichtenstein, Paul; Ljung, Therese; Nelson, Nina; Larsson, Henrik; Anckarsäter, Henrik // Twin Research & Human Genetics;Dec2011, Vol. 14 Issue 6, p553 

    Background: The normal development of cortisol regulation during childhood is thought to be influenced by a complex interplay between environmental and genetic factors.Method: The aim of this study was to estimate genetic and environmental influences on basal cortisol...

  • Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia? Asherson, Philip; Walsh, Cathy; Williams, Julie; Sargeant, Mathew; Taylor, Celia; Clements, Alison; Gill, Michael; Owen, Michael; McGuffin, Peter; Asherson, P; Walsh, C; Williams, J; Sargeant, M; Taylor, C; Clements, A; Gill, M; Owen, M; McGuffin, P // British Journal of Psychiatry;May94, Vol. 164, p619 

    Among 29 multiply affected pedigrees, age of onset among parents and offspring was examined for evidence of both anticipation and genomic imprinting. The results do not suggest that either mechanism is operating in schizophrenia, but only very large effects can be confidently excluded.

  • Epidemiology of the mitochondrial DNA 8344A>G mutation for the myoclonus epilepsy and ragged red fibres (MERRF) syndrome. Remes, A. M.; Kärppä, M.; Moilanen, J. S.; Rusanen, H.; Hassinen, I. E.; Majamaa, K.; Uimonen, S.; Sorri, M.; Salmela, P. I.; Karvonen, S-L; Kärppä, M // Journal of Neurology, Neurosurgery & Psychiatry;Aug2003, Vol. 74 Issue 8, p1158 

    No abstract available.

  • (CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China. Zhao Chen; Caifa Zheng; Zhe Long; Li Cao; Xunhua Li; Huifang Shang; Xinzhen Yin; Baorong Zhang; Jingyu Liu; Dongxue Ding; Yun Peng; Chunrong Wang; Huirong Peng; Wei Ye; Rong Qiu; Qian Pan; Kun Xia; Shengdi Chen; Sequeiros, Jorge; Tetsuo Ashizawa // Brain: A Journal of Neurology;8/1/2016, Vol. 139 Issue 8, p1 

    No abstract available.

  • Polymorphism of codon 72 of p53 and environmental factors in the development of cervical cancer Jee, S.H.; Lee, J.E.; Park, J.S. // International Journal of Gynecology & Obstetrics;Jan2003, Vol. 80 Issue 1, p69 

    No abstract available.

  • Genetic susceptibility to the respiratory effects of air pollution. Yang, I. A.; Fong, K. M.; Zimmerman, P. V.; Holgate, S. I.; Holloway, J. W.; Holgate, S T // Thorax;Jun2008, Vol. 63 Issue 6, p555 

    There is large variation between individuals in their response to air pollutants. This review summarises the existing evidence that genetic factors influence the mechanisms of lung injury caused by air pollutants. Genetic association studies have compared the adverse effects of air pollutants...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics