TITLE

Association studies for asthma and atopic diseases: a comprehensive review of the literature

AUTHOR(S)
Hoffjan, Sabine; Nicolae, Dan; Ober, Carole
PUB. DATE
January 2003
SOURCE
Respiratory Research;2003, Vol. 4, p14
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.
ACCESSION #
30729707

 

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