TITLE

Notch signaling in mammalian hematopoietic stem cells

AUTHOR(S)
Pajcini, K V; Speck, N A; Pear, W S
PUB. DATE
October 2011
SOURCE
Leukemia (08876924);Oct2011, Vol. 25 Issue 10, p1525
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Notch is a crucial cell signaling pathway in metazoan development. By means of cell-cell interactions, Notch signaling regulates cellular identity, proliferation, differentiation and apoptosis. Within the last decade, numerous studies have shown an important role for this pathway in the development and homeostasis of mammalian stem cell populations. Hematopoietic stem cells (HSCs) constitute a well-defined population that shows self-renewal and multi-lineage differentiation potential, with the clinically relevant capacity to repopulate the hematopoietic system of an adult organism. Here, we review the emergence, development and maintenance of HSCs during mammalian embryogenesis and adulthood, with respect to the role of Notch signaling in hematopoietic biology.
ACCESSION #
66445243

 

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