TITLE

Herpes simplex virus resistant to acyclovir. A study in a tertiary care center

AUTHOR(S)
Englund, Janet A.; Zimmerman, Mark E.; Swierkosz, Ella M.; Goodman, Jesse L.; Scholl, David R.; Balfour Jr., Henry H.; Englund, J A; Zimmerman, M E; Swierkosz, E M; Goodman, J L; Scholl, D R; Balfour, H H Jr
PUB. DATE
March 1990
SOURCE
Annals of Internal Medicine;3/15/90, Vol. 112 Issue 6, p416
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Study Objective: To determine the sensitivity of herpes simplex virus isolates to acyclovir and the importance of resistant isolates in hospitalized patients.Design: Retrospective incidence cohort study.Setting: All herpes simplex virus isolates cultured over 1 year from patients followed at a tertiary care center.Patients: Consecutive herpes simplex virus isolates were collected from 207 patients, including immunocompetent patients, patients with malignancy, neonates, bone marrow and organ transplant recipients, and patients seropositive for human immunodeficiency virus.Measurements and Main Results: A rapid nucleic acid hybridization method was used to assess susceptibility to acyclovir. Acyclovir-resistant herpes simplex viruses were recovered from 7 of 148 immunocompromised patients (4.7%) but from none of 59 immunocompetent hosts. Clinical disease was found in all 7 patients with resistant herpes simplex virus and was more severe in pediatric patients. All resistant isolates were from acyclovir-treated patients and had absent or altered thymidine kinase activity by plaque autoradiography.Conclusion: Herpes simplex virus resistant to acyclovir arises relatively frequently in immunocompromised patients and may cause serious disease. Rapid detection of resistance permits antiviral therapy to be individualized. Antiviral susceptibility testing to monitor viral resistance should be encouraged, especially in tertiary care settings.
ACCESSION #
6965614

 

Related Articles

  • Recurrent antiviral-resistant genital herpes in an immunocompetent patient. Kriesel, John D.; Spruance, Spotswood L.; Prichard, Mark; Parker, Jacqueline N.; Kern, Earl R. // Journal of Infectious Diseases;7/1/2005, Vol. 192 Issue 1, p156 

    Herpes simplex virus type 2 (HSV-2) resistance to antiviral drugs has been described primarily in immunocompromised patients. We report an apparently immunocompetent, human immunodeficiency virus-negative male patient who has experienced repeated HSV-2 genital outbreaks despite receiving...

  • Estimating the costs and benefits of screening monogamous, heterosexual couples for unrecognised infection with herpes simplex virus type 2. Fisman, D.N.; Hook III, E.W.; Goldie, S.J.; Hook, E W 3rd // Sexually Transmitted Infections;Feb2003, Vol. 79 Issue 1, p45 

    Objectives: Herpes simplex virus type 2 (HSV-2) is the most common cause of ulcerative genital disease in the United States, but infection is commonly unrecognised. Serological screening tests could identify discordantly infected couples and permit targeted interventions to limit...

  • Patterns of herpes simplex virus shedding over 1 month and the impact of acyclovir and HIV in HSV-2-seropositive women in Tanzania. Tanton, Clare; Weiss, Helen A; LeGoff, Jerome; Changalucha, John; Clayton, Tim C; Ross, David A; Belec, Laurent; Hayes, Richard J; Watson-Jones, Deborah // Sexually Transmitted Infections;Aug2011, Vol. 87 Issue 5, p406 

    Objectives: Few studies have examined the frequency and duration of genital herpes simplex virus (HSV) shedding in sub-Saharan Africa. This study describes HSV shedding patterns among a sample of HSV-2-seropositive women enrolled in a placebo-controlled trial of HSV suppressive...

  • Acyclovir Susceptibility and Genetic Characteristics of Sequential Herpes Simplex Virus Type 1 Corneal Isolates from Patients with Recurrent Herpetic Keratitis. Rui Duan; de Vries, Rory D.; van Dun, Jessica M.; van Loenen, Freek B.; Osterhaus, Albert D. M. E.; Remeijer, Lies; Verjans, Georges M. G. M. // Journal of Infectious Diseases;11/1/2009, Vol. 200 Issue 9, p1402 

    Purpose. The incidence and clinical significance of herpes simplex virus type 1 (HSV-1) acyclovir resistance were determined in patients with recurrent herpetic keratitis (RHK). Methods. Sequential corneal isolates (n=39) from 15 immunocompetent patients with RHK were assayed for acyclovir...

  • Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population. Darville, J M; Ley, B E; Roome, A P C H; Foot, A B M // Bone Marrow Transplantation;9/15/98, Vol. 22 Issue 6, p587 

    Over a 3-month period, four patients who had received unrelated donor (UD) bone marrow transplants (BMT) presented with severe mucocutaneous herpes simplex virus (HSV) infection while receiving acyclovir (ACV) prophylaxis. Sensitivity testing of the isolates revealed three to be...

  • Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. Huang, Laurence; Crothers, Kristina; Atzori, Chiara; Benfield, Thomas; Miller, Robert; Rabodonirina, Meja; Helweg-Larsen, Jannik // Emerging Infectious Diseases;Oct2004, Vol. 10 Issue 10, p1721 

    Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis. While prophylaxis has reduced the incidence of PCP, its use has raised concerns about...

  • Modeling the HIV protease inhibitor adherence-resistance curve by use of empirically derived estimates. Bangsberg, David R.; Porco, Travis C.; Kagay, C.; Charlebois, Edwin D.; Deeks, Steven G.; Guzman, David; Clark, Richard; Moss, Andrew // Journal of Infectious Diseases;7/1/2004, Vol. 190 Issue 1, p162 

    The standard view postulates a bell-shaped relationship between adherence to therapy and development of drug-resistant human immunodeficiency virus (HIV), with a resistance peak at a moderate level of adherence. This relationship has not been confirmed empirically. We statistically modeled the...

  • Independent Nurse: Clinical - Sexual health - Controlling genital herpes - Infection. Bickford, Jane // GP: General Practitioner;1/20/2006, p104 

    The article presents information about genital herpes. Human herpes simplex virus is the most common cause of genital ulceration in Great Britain. In countries where HIV is more common, genital ulcerative disease is an important factor to consider with respect to HIV transmission. Genital herpes...

  • In vitro inhibitory effects of chlorhexidine and Persica mouthwashes on HSV-1 compared with acyclovir. Poorshahidi, Sara; Davarmanesh, Mehdi; Rezazadeh, Fahimeh; Motamedifar, Mohammad; Ebrahimi, Hooman; Alipour, Abbas // Journal of Isfahan Dental School;Mar2011, Special section p1 

    Introduction: Recurrent intraoral herpes is a common oral disease that causes painful ulcers and viral shedding, resulting in various complications for patients. The antiviral efficacy of oral mouthwashes has not been adequately studied, although they are a readily available and rapid treatment...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics