TITLE

Exercise and lumbar spine bone mineral density in postmenopausal women: a meta-analysis of individual patient data

AUTHOR(S)
Kelley, George A.; Kelley, Kristi S.; Zhung Vu Tran; Tran, Zung Vu
PUB. DATE
September 2002
SOURCE
Journals of Gerontology Series A: Biological Sciences & Medical ;Sep2002, Vol. 57 Issue 9, pM599
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Background: Low bone mineral density (BMD) at the lumbar spine is a major public health problem among postmenopausal women. We conducted a meta-analysis of individual patient data (IPD) to examine the effects of exercise on lumbar spine BMD in postmenopausal women.Methods: IPD were requested from a previously developed database of summary means from randomized and nonrandomized trials dealing with the effects of exercise on BMD. Two-way analysis of variance tests with pairwise comparisons (p < or =.05) and 95% confidence intervals (CIs) were used to determine the statistical significance for changes in lumbar spine BMD.Results: Across 13 trials that included 699 subjects (355 exercise, 344 control), a statistically significant interaction was found between test and group (F = 15.232, p =.000). Pairwise comparisons (Bonferroni t tests) revealed a statistically significant increase in final minus initial BMD for the exercise group ( +/- SD = 0.005 +/- 0.043 g/cm(2), t = 2.46, p =.014, 95% CI = 0.001-0.009) and a statistically significant decrease in final minus initial BMD for the control group ( +/- SD = -0.007 +/- 0.045 g/cm(2), t = -3.051, p =.002, 95% CI = -0.012--0.002). Changes were equivalent to an approximate 2% benefit in lumbar spine BMD (exercise, +1%, control, -1%).Conclusions: The results of this IPD meta-analysis suggest that exercise helps to improve and maintain lumbar spine BMD in postmenopausal women.
ACCESSION #
7342701

 

Related Articles

  • Identification and Fracture Outcomes of Undiagnosed Low Bone Mineral Density in Postmenopausal Women. Siris, Ethel S.; Miller, Paul D.; Barrett-Connor, Elizabeth; Faulkner, Kenneth G.; Wehren, Lois E.; Abbott, Thomas A.; Berger, Marc L.; Santora, Arthur C.; Sherwood, Louis M. // JAMA: Journal of the American Medical Association;12/12/2001, Vol. 286 Issue 22, p2815 

    Reports on a study to describe the occurrence of low bone mineral density in post-menopausal women, its risk factors, and fracture incidence during short-term follow-up. Design; Setting and participants; Main outcome measures; Results; Conclusion that strategies to identify and manage...

  • Should prescription of postmenopausal hormone therapy be based on the results of bone densitometry? Cummings, Stephen R.; Browner, Warren S.; Ettinger, Bruce; Cummings, S R; Browner, W S; Grady, D; Ettinger, B // Annals of Internal Medicine;10/15/90, Vol. 113 Issue 8, p565 

    Editorial. Comments on a study which suggested the use of bone densitometry to help women decide whether to undergo postmenopausal hormone therapy. Assumptions concerning the risk for coronary heart disease among women; Issues on cost-effectiveness; Criticisms against the use of bone...

  • Thin your waist, not your bones. McVeigh, Gloria // Prevention;Mar2005, Vol. 57 Issue 3, p80 

    Focuses on the importance of calcium in women's nutrition. Statement that women on diets need more calcium to prevent bone loss; Report that weight loss cuts absorption of bone-building calcium in postmenopausal dieters.

  • Cost effectiveness of screening perimenopausal white women for osteoporosis: bone densitometry and hormone replacement therapy. Tosteson, Abba N.A.; Rosenthal, Daniel I.; Melton, Joseph; Weinstein, Milton C.; Tosteson, A N; Rosenthal, D I; Melton, L J 3rd; Weinstein, M C // Annals of Internal Medicine;10/15/90, Vol. 113 Issue 8, p594 

    Bone mass measurement at menopause to identify and selectively prescribe hormone replacement therapy for women at high risk for fractures has seen limited clinical use. We used epidemiologic, clinical, and economic data in a decision-analytic model to compare the following clinical strategies...

  • Forearm Bone Mineral Density by Age in 7,620 Men and Women The Tromsø Study, a Population-based Study. Berntsen, Gro K. Rosvold; Fønnebø, Vinjar; Tollan, Anne; Søgaard, Anne Johanne; Magnus, Jeanette H. // American Journal of Epidemiology;Mar2001, Vol. 153 Issue 5, p465 

    Population-based studies of adult forearm bone mineral density (BMD) by age are scarce, and standardized reference values are lacking. In this cross-sectional study, men aged 55–74 years, women aged 50–74 years, and representative 5–10% samples of remaining age groups...

  • An Assessment Tool for Predicting Fracture Risk in Postmenopausal Women. Black, D. M.; Steinbuch, M.; Palermo, L.; Dargent-Molina, P.; Lindsay, R.; Hoseyni, M. S.; Johnell, O. // Osteoporosis International;Aug2001, Vol. 12 Issue 7, p519 

    : Due to the magnitude of the morbidity and mortality associated with untreated osteoporosis, it is essential that high-risk individuals be identified so that they can receive appropriate evaluation and treatment. The objective of this investigation was to develop a simple clinical assessment...

  • Weight and Body Mass Index at Menarche are Associated with Premenopausal Bone Mass. Blum, M.; Harris, S. S.; Must, A.; Phillips, S. M.; Rand, W. M.; Dawson-Hughes, B. // Osteoporosis International;Aug2001, Vol. 12 Issue 7, p588 

    : Adolescence is a critical time for skeletal growth and mineralization. Exposure to protective or detrimental factors during this period may influence peak bone mass attainment and subsequent development of osteoporosis. In order to evaluate the association of body size during adolescence with...

  • Exercise After Menopause Shows Benefits. SerVaas, Cory // Medical Update;2005, Vol. 30 Issue 11/12, p2 

    This article discusses a study conducted by researchers at the University of Erlangen in Germany in 2005 on the benefits of exercise after menopause to women. Study participants were women in early menopause who showed signs of calcium loss from the spine or hip. The exercise group performed...

  • Performance of the Osteoporosis Self-Assessment Tool in ruling out low bone mineral density in postmenopausal women: a systematic review. Rud, B.; Hilden, J.; Hyldstrup, L.; Hróbjartsson, A. // Osteoporosis International;Sep2007, Vol. 18 Issue 9, p1177 

    The Osteoporosis Self-Assessment Tool (OST) is a simple test that may be of clinical value to rule-out low bone mineral density. We performed a systematic review to assess its performance in postmenopausal women. We included 36 studies. OST performed moderately in ruling-out femoral neck T-score...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics