TITLE

Cost effectiveness of recombinant human insulin-like growth factor I therapy in patients with ALS

AUTHOR(S)
Ackerman, S.J.; Sullivan, E.M.; Beusterien, K.M.; Natter, H.M.; Gelinas, D.F.; Patrick, D.L.
PUB. DATE
February 1999
SOURCE
PharmacoEconomics;1999, Vol. 15 Issue 2, p179
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: Amyotrophic lateral sclerosis (ALS) is a fatal, degenerative neuromuscular disease characterised by a progressive loss of voluntary motor activity. Recombinant human insulin-like growth factor I (rhIGF-I) has been shown to be useful in treating ALS. The purpose of this study was to examine the cost effectiveness of rhIGF-I therapy in patients who have ALS.Design: We performed a cost-effectiveness analysis from the societal perspective on 177 patients who received treatment with rhIGF-I or placebo in a North American randomised clinical trial. We estimated the incremental cost-effectiveness ratio of rhIGF-I using resource utilisation and functional status measurements from the clinical trial. Costs were estimated from 1996 US Medicare reimbursement schedules. Utility weights were elicited from ALS healthcare providers using the standard gamble technique.Main Outcome Measures and Results: The overall cost per quality-adjusted life-year (QALY) gained for rhIGF-I therapy compared with placebo was $US67,440. For the subgroups of patients who were progressing rapidly or were in earlier stages of disease at enrolment, rhIGF-I cost $US52,823 and $US43,197 per QALY gained, respectively.Conclusions: Treatment with rhIGF-I is most cost effective in ALS patients who are either in earlier stages of the disease or progressing rapidly. The cost effectiveness of rhIGF-I therapy compares favourably with treatments for other chronic progressive diseases.
ACCESSION #
9526781

 

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