TITLE

Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

AUTHOR(S)
Creutzig, U; Dworzak, M N; Zimmermann, M; Bourquin, J-P; Gruhn, B; Fleischhack, G; Graf, N; Klingebiel, T; Kremens, B; Lehrnbecher, T; von Neuhoff, C; Stackelberg, A v; StarĂ½, J; Reinhardt, D
PUB. DATE
November 2015
SOURCE
Leukemia (08876924);Nov2015, Vol. 29 Issue 11, p2260
SOURCE TYPE
Academic Journal
DOC. TYPE
letter
ABSTRACT
The article discusses a study which aimed to improve outcome of high-risk (HR) patients by adding moderately dosed 2-chloro-2-deoxyadenosine (2-CDA) to the respective consolidation treatment backbone without increasing the toxicity. The treatment plan included randomization during induction with either liposomal daunorubicin or idarubicin. It suggests that moderate dose 2-CDA does not improve prognosis in HR patients when given during consolidation treatment.
ACCESSION #
110690525

 

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