TITLE

Direct Reprogramming

AUTHOR(S)
Marbán, Eduardo; Cingolani, Eugenio
PUB. DATE
July 2015
SOURCE
JAMA: Journal of the American Medical Association;7/7/2015, Vol. 314 Issue 1, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
The authors comment on the direct reprogramming of stem cells for therapeutics. Topics covered include concerns that have restricted in vivo applications of tissues and organs to be recreated from embryonic stem cells, the limitations of induced stem cells as well as the complexity of reprogramming, and the stalled translation of direct reprogramming to the clinic.
ACCESSION #
103710930

 

Related Articles

  • Long-term clinical outcomes after fetal cell transplantation in parkinson disease: implications for the future of cell therapy. Bega, Danny; Krainc, Dimitri // JAMA: Journal of the American Medical Association;2/12/2014, Vol. 311 Issue 6, p617 

    IMPORTANCE: Recent advances in stem cell technologies have rekindled an interest in the use of cell replacement strategies for patients with Parkinson disease. This study reports the very long-term clinical outcomes of fetal cell transplantation in 2 patients with Parkinson disease. Such...

  • Stem cell therapy takes a giant leap.  // New Scientist;8/23/2008, Vol. 199 Issue 2670, p5 

    The author reflects on the use of embryonic stem cells (ESCs) to repair damaged spinal cords, hearts, livers, bones and pancreas.

  • Stem cell progress. Coghlan, Andy // New Scientist;1/28/2012, Vol. 213 Issue 2849, p7 

    The article discusses a report published in "The Lancet" by scientist Robert Lanza and colleagues that found that the vision of patients with retinal degradation improved after treatment with an injection of human embryonic stem cells.

  • SCL/TAL1 Regulates Hematopoietic Specification From Human Embryonic Stem Cells. Real, Pedro J; Ligero, Gertrudis; Ayllon, Veronica; Ramos-Mejia, Veronica; Bueno, Clara; Gutierrez-Aranda, Ivan; Navarro-Montero, Oscar; Lako, Majlinda; Menendez, Pablo // Molecular Therapy;Jul2012, Vol. 20 Issue 7, p1443 

    Determining the molecular regulators/pathways responsible for the specification of human embryonic stem cells (hESCs) into hematopoietic precursors has far-reaching implications for potential cell therapies and disease modeling. Mouse models lacking SCL/TAL1 (stem cell leukemia/T-cell acute...

  • Selling Out for Science. Guterl, Fred; Cunningham, Jaime; Raymond, Joan; Brownell, Ginanne // Newsweek (Atlantic Edition);11/8/2004 (Atlantic Edition), Vol. 144 Issue 19, p54 

    Focuses on the debate over stem cells in the United States. Claim that some scientists have exaggerated stem cells' potential for cures; Reference to a proposition in California that would give $3 billion to human embryonic stem cell research; Research conducted by Hans Kierstead of the...

  • Selling Out for Science. Guterl, Fred; Cunningham, Jaime; Raymond, Joan; Brownell, Ginanne // Newsweek (Pacific Edition);11/8/2004 (Pacific Edition), Vol. 144 Issue 19, p46 

    Focuses on the debate over stem cells in the United States. Claim that some scientists have exaggerated stem cells' potential for cures; Reference to a proposition in California that would give $3 billion to human embryonic stem cell research; Research conducted by Hans Kierstead of the...

  • Stem Cells: The survival of the fittest. Pastrana, Erika // Nature Methods;Jan2012, Vol. 9 Issue 1, p16 

    The article offers information on a research regarding human embryonic stem cells (ESCs) lines which shows that genetic change may affect the growth advantage.

  • PPARγ Agonists Treatment Did Not Significantly Enhance The Expression Levels of Neural Precursor Cell Markers during Neural Differentiation of Human Embryonic Stem Cells. Taheri, M.; Salamian, A.; Ghaedi, K.; Nasr Esfahani, M. H.; Baharvand, H. // Cell Journal (Yakhteh);Summer 2013 Supplement 1, Vol. 15 Issue Sup 1, p81 

    Objective: Human embryonic stem cells (hESCs) are pluripotent cells that have the potential to differentiate into various cell types such as neural differentiation. PPARγ (peroxisome proliferator-activated receptor gamma) is a member of the nuclear receptors, which exerts various metabolic...

  • New Stem-Cell Method Shows Promise.  // America;3/3/2014, Vol. 210 Issue 7, p10 

    The article discusses studies published in the January 29, 2014 issue of the journal "Nature" about the use of the stimulus-triggered acquisition of pluripotency (STAP) method to create stem cells by manipulating existing cells and to reduce the need for research involving human embryos.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics