TITLE

Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel

AUTHOR(S)
Ramirez, Andrea H; Delaney, Jessica T; Shuldiner, Alan R
PUB. DATE
August 2011
SOURCE
Evidence Based Medicine;Aug2011, Vol. 16 Issue 4, p124
SOURCE TYPE
Academic Journal
DOC. TYPE
Opinion
ABSTRACT
The article presents a commentary on the study "Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis," published in a 2010 issue of the "Journal of American Medical Association." It notes the failure of the study to address the concurrent use of proton pump inhibitors, which can inhibit the activity of the cytochrome P450 gene. Information on alternative treatment strategies is also provided.
ACCESSION #
66315524

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics