Brief Report: Childhood Disintegrative Disorder as a Likely Manifestation of Vitamin B12 Deficiency

Malhotra, Savita; Subodh, B.; Parakh, Preeti; Lahariya, Sanjay
September 2013
Journal of Autism & Developmental Disorders;Sep2013, Vol. 43 Issue 9, p2207
Academic Journal
Childhood disintegrative disorder is a rare disorder, characterized by regression of acquired skills after a period of normal development. The case of childhood disintegrative disorder presented here was found to have vitamin B12 deficiency and hyperhomocysteinemia on extensive evaluation to find a probable cause for regression. This case illustrates the need for a thorough evaluation of all cases of childhood disintegrative disorder so that treatable causes of regression, like vitamin B12 deficiency, are not missed.


Related Articles

  • Comment on the paper 'Pervasive Refusal Syndrome (PRS) 21 years on-a reconceptualization and renaming' by Ken Nunn, Bryan Lask and Isabel Owen. Bodegård, Göran // European Child & Adolescent Psychiatry;Mar2014, Vol. 23 Issue 3, p179 

    The author discusses the study on the pervasive refusal syndrome (PRS) of children in Sweden. The author states that the accumulation of hundreds of children with symptoms corresponding to PRS created possibility of scientific standardized studies. It mentions that the situation in Sweden...

  • Autism spectrum disorders: an overview on diagnosis and treatment. Brentani, Helena; Silvestre de Paula, Cristiane; Bordini, Daniela; Rolim, Deborah; Sato, Fabio; Portolese, Joana; Pacifico, Maria Clara; McCracken, James T. // Revista Brasileira de Psiquiatria;Mar2013 supplement, Vol. 35 Issue S1, pS62 

    Pervasive developmental disorders are now commonly referred to as autism spectrum disorders (ASDs). ASDs present with a range of severity and impairments, and often are a cause of severe disability, representing a major public health concern. The diagnostic criteria require delays or abnormal...

  • Maternal folic acid supplements associated with reduced autism risk in the child. Schmidt, Rebecca J. // Evidence Based Medicine;Dec2013, Vol. 18 Issue 6, . pe53 

    The author reflects on the study titled "Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children" by P. Surén and colleagues published in a 2013 issue of the "Journal of the American Medical Association." Topics include the effect of...

  • Childhood disintegrative disorder. Charan, Sri Hari // Journal of Pediatric Neurosciences;Jan-Apr2012, Vol. 7 Issue 1, p55 

    We are presenting a case of a 10-year-old female child who presented with normal development till 5 years of age followed by deterioration in previously acquired language and social skills with stereotypic hand movements suggestive of childhood disintegrative disorder. This case is reported as...

  • Childhood Disintegrative Disorder: Distinction From Autistic Disorder and Predictors of Outcome. Rosman, N. Paul; Bergia, Berta M. // Journal of Child Neurology;Dec2013, Vol. 28 Issue 12, p1587 

    Childhood disintegrative disorder, a rare, relentlessly progressive neurologic disorder, first described by Heller in 1908, remains a condition of great interest. It has long been debated whether it is a discrete disorder or simply a late-onset variant of childhood autism. We have studied 6...

  • The relationship between Asperger's syndrome and schizophrenia in adolescence. Waris, Petra; Lindberg, Nina; Kettunen, Kirsi; Tani, Pekka // European Child & Adolescent Psychiatry;Apr2013, Vol. 22 Issue 4, p217 

    Asperger's syndrome (AS), a pervasive developmental disorder (PDD), has nowadays been widely advocated in media. Therefore, psychiatrists treating adolescents frequently meet patients as well as their families reporting of symptoms resembling those of Asperger's syndrome. It is known that...

  • Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism? Hrdlicka, Michal; Vacova, Maria; Oslejskova, Hana; Gondzova, Veronika; Vadlejchova, Iveta; Kocourkova, Jana; Koutek, Jiri; Dudova, Iva // Neuropsychiatric Disease & Treatment;Jul2016, Vol. 12, p1639 

    Background: The marked increase in autism spectrum disorders (ASD) prevalence has stimulated worldwide interest in exploring broader circumstances of care of autistic children, including the role of socioeconomic status (SES) and family information on autism. Methods: Our sample comprised of 160...

  • Autism spectrum disorder in adults: diagnosis, management, and health services development. Murphy, Clodagh M.; Wilson, C. Ellie; Robertson, Dene M.; Ecker, Christine; Daly, Eileen M.; Hammond, Neil; Galanopoulos, Anastasios; Dud, Iulia; Murphy, Declan G.; McAlonan, Grainne M. // Neuropsychiatric Disease & Treatment;Jul2016, Vol. 12, p1669 

    Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by pervasive difficulties since early childhood across reciprocal social communication and restricted, repetitive interests and behaviors. Although early ASD research focused primarily on children, there is...

  • Concerns Expressed by Parents of Children with Pervasive Developmental Disorders for Different Time Periods of the Day: A Case–Control Study. Sasaki, Yoshinori; Usami, Masahide; Sasayama, Daimei; Okada, Takashi; Iwadare, Yoshitaka; Watanabe, Kyota; Ushijima, Hirokage; Tanaka, Tetsuya; Harada, Maiko; Tanaka, Hiromi; Kodaira, Masaki; Sugiyama, Nobuhiro; Sawa, Tetsuji; Saito, Kazuhiko // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Background/Aim: The Questionnaire: Children with Difficulties (QCD) is a parent-assessed questionnaire designed to evaluate child’s difficulties in functioning during specific periods of the day. This study aimed to evaluate difficulties in daily functioning of children and adolescents...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics